AL Hevener, D Reichart, A Janez, J Olefsky - Diabetes, 2001 - Am Diabetes Assoc We sought to ascertain whether pretreatment with troglitazone (20 days) could prevent acute
free fatty acid (FFA)–induced insulin resistance in male Wistar rats. Animals were divided into
three groups: 1) control, 2) FFA infusion alone (FFA1), and 3) thiazolidinedione (TZD)- ... Cited by 76 - Related articles - BL Direct - All 5 versions
- ►endojournals.org JM Ye, G Frangioudakis, MA Iglesias, SM Furler, B Ellis … - Endocrinology, 2002 - Endocrine Soc Thiazolidinediones lower lipids, but it is unclear whether this is essential for their insulin-sensitizing
action. We investigated relationships between lipid-lowering and insulin-sensitizing actions of
a thiazolidinedione. Normal rats were pretreated with or without Pioglitazone (Pio, 3 ... Cited by 32 - Related articles - BL Direct - All 6 versions
A Hevener, D Reichart, A Janez, J Olefsky - Diabetes, 2002 - Am Diabetes Assoc It is well described that excessive lipid metabolism can cause insulin resistance in both animals
and humans, and this has been implicated as a causative factor in the development of insulin
resistance and type 2 diabetes in humans. Recently, we have shown that intravenous ... Cited by 32 - Related articles - BL Direct - All 6 versions
- ►endojournals.org S Dhindsa, D Tripathy, N Sanalkumar, S … - Journal of Clinical …, 2005 - Endocrine Soc Results: After rosiglitazone for 6 wk, fasting FFA concentration fell, but not significantly (489 ±
63 at 0 wk; 397 ± 58 µmol/liter at 6 wk; P = 0.16), whereas C-reactive protein (4.26 ± 0.95 at 0
wk; 2.03 ± 0.45 µg/ml at 6 wk) and serum amyloid A (17.36 ± 4.63 at 0 wk; 8.77 ± 1.63 ... Cited by 16 - Related articles - BL Direct - All 5 versions
- ►endojournals.org MJ Watt, A Hevener, GI Lancaster, MA Febbraio - Endocrinology, 2006 - Endocrine Soc Ciliary neurotrophic factor (CNTF) is a member of the gp130 receptor cytokine family recently
identified as an antiobesity agent in rodents and humans by mechanisms that remain
unclear. We investigated the impact of acute CNTF treatment on insulin action in the ... Cited by 36 - Related articles - All 5 versions
- ►jbc.org N Qi, L Kazdova, V Zidek, V Landa, V Kren, HA … - Journal of Biological …, 2002 - ASBMB Pioglitazone, like other thiazolidinediones, is an insulin-sensitizing agent that activates the peroxisome
proliferator-activated receptor and influences the expression of multiple genes involved in carbohydrate
and lipid metabolism. However, it is unknown which of these many target genes play ... Cited by 46 - Related articles - BL Direct - All 5 versions
SB Racette, AO Davis, JB McGill, S Klein - Metabolism, 2002 - Elsevier Type 2 diabetes mellitus is characterized by insulin-resistant glucose and lipid metabolism. Thiazolidinediones
(TZDs) enhance insulin-mediated glucose disposal, but their effects on lipid kinetics are
unknown. We evaluated the effect of the TZD troglitazone on insulin-mediated ... Cited by 29 - Related articles - BL Direct - All 7 versions
G Boden, P Cheung, M Mozzoli, SK Fried - Metabolism, 2003 - Elsevier The current study aimed to compare the effects of treatment (2 months) with thiazolidinediones
(TZDs) and placebo on glucose and fat metabolism in patients with type 2 diabetes (T2DM) in
a crossover design. Eight patients received placebo (2 months) followed by TZD (2 ... Cited by 70 - Related articles - All 10 versions
- ►jbc.org BM Jucker, AJM Rennings, GW Cline, GI Shulman - Journal of Biological …, 1997 - ASBMB The effects of increased plasma free fatty acids (FFA) on insulin-dependent whole body glucose
disposal, skeletal muscle glycolysis, glycogen synthesis, pyruvate versus FFA/ketone
oxidation, and glucose 6-phosphate (Glu-6-P) were investigated in the awake rat. A ... Cited by 56 - Related articles - BL Direct - All 6 versions
