M Li, JF Youngren, VP Manchem, M Kozlowski … - Diabetes, 2001 - Am Diabetes Assoc In type 2 diabetes, impaired insulin signaling leads to hyperglycemia and other
metabolic abnormalities. To study a new class of antidiabetic agents, we
compared two small, nonpeptide molecules that activate insulin receptor ... Cited by 21 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org VP Manchem, ID Goldfine, RA Kohanski, CP … - Diabetes, 2001 - Am Diabetes Assoc Insulin resistance, an important feature of type 2 diabetes, is manifested as
attenuated insulin receptor (IR) signaling in response to insulin binding. A
drug that promotes the initiation of IR signaling by enhancing IR ... Cited by 28 - Related articles - BL Direct - All 10 versions
- ►jbc.org SA Qureshi, V Ding, Z Li, D Szalkowski, DE … - Journal of Biological Chemistry, 2000 - ASBMB We recently described the identification of a non-peptidyl fungal metabolite
(L-783,281, compound 1), which induced activation of human insulin receptor (IR)
tyrosine kinase and mediated insulin-like effects in cells, as well as ... Cited by 40 - Related articles - BL Direct - All 3 versions
C Pender, ID Goldfine, VP Manchem, JL Evans … - Journal of Biological Chemistry, 2002 - ASBMB In type 2 diabetes mellitus, impaired insulin signaling leads to hyperglycemia
and other metabolic abnormalities. TLK19780, a non-peptide small molecule, is a
new member of a novel class of anti-diabetic agents that function as ... Cited by 14 - Related articles - BL Direct - All 4 versions
GM Salituro, F Pelaez, BB Zhang - Recent Progress in Hormone Research, 2001 - Endocrine Soc GINO M. SALITURO,* FERNANDO PELAEz,t AND BEI B. ZHANG~ *Department of Natural
Product Drug Discovety, t Department of Molecular Endocrinologv RSOW250, Merck
Research Laboratories, Rahway New Jersey 07065; SCentro de Investigaci6n ... Cited by 24 - Related articles - BL Direct - All 2 versions
K Liu, L Xu, D Szalkowski, Z Li, V Ding, G … - J. Med. Chem, 2000 - pubs.acs.org A series of 3,6-diaryl-2,5-dihydroxybenzoquinones were synthesized and evaluated
for their abilities to selectively activate human insulin receptor tyrosine
kinase (IRTK). 2,5-Dihydroxy-6-(1-methylindol-3-yl)-3-phenyl-1,4- ... Cited by 47 - Related articles - BL Direct - All 5 versions
- ►endojournals.org MZ Strowski, Z Li, D Szalkowski, X Shen, XM … - Endocrinology, 2004 - Endocrine Soc Adiposity positively correlates with insulin resistance and is a major risk
factor of type 2 diabetes. Administration of exogenous insulin, which acts as an
anabolic factor, facilitates adipogenesis. Recently nonpeptidal insulin ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] VDH Ding, SA Qureshi, D Szalkowski, Z Li, DE … - Biochemical Journal, 2002 - pubmedcentral.nih.gov Insulin regulates cellular metabolism and growth through ac- tivation of insulin
receptors (IRs). We recently identified a non- peptide small-molecule IR
activator (compound 2), which induced human IR tyrosine kinase activity in ... Cited by 16 - Related articles - BL Direct - All 6 versions
ID Goldfine - The Journal of laboratory and clinical medicine, 1999 - Elsevier EDITORIALS Unraveling the riddle of insulin resistance Abbreviations: IR =
insulin receptor; PTPIB = protein tyrosine phosphatase IB; TNFc = tumor necrosis
factorc D iabetes mellitus is a major health problem in the United States, ... Cited by 7 - Related articles - BL Direct - All 5 versions
E Laborde, VP Manchem - Frontiers in Medicinal Chemistry-Online, 2004 - ingentaconnect.com Telik, Inc., Departments of Chemistry and Biology, 3165 Porter Drive, Palo Alto,
CA 94304-1213, USA Abstract : Diabetes Mellitus refers to a spectrum of
syndromes characterized by abnormally high levels of glucose in blood. ... Cited by 2 - Related articles - BL Direct - All 4 versions
