A Virkamäki, E Korsheninnikova, A Seppälä-Lindroos, … - Diabetes, 2001 - Am Diabetes Assoc To examine whether and how intramyocellular lipid (IMCL) content contributes to interindividual
variation in insulin action, we studied 20 healthy men with no family history of type 2
diabetes. IMCL was measured as the resonance of intramyocellular CH 2 protons in lipids/ ... Cited by 148 - Related articles - BL Direct - All 6 versions
S Jacob, J Machann, K Rett, K Brechtel, A … - DIABETES-NEW …, 1999 - Am Diabetes Assoc Insulin resistance plays an important role in the patho- genesis of type 2 diabetes; however, the
multiple mech- anisms causing insulin resistance are not yet fully understood. The aim of this
study was to explore the pos- sible contribution of intramyocellular lipid content in the ... Cited by 361 - Related articles - BL Direct - All 4 versions
OP Bachmann, DB Dahl, K Brechtel, J Machann, M … - Diabetes, 2001 - Am Diabetes Assoc An increased intramyocellular lipid (IMCL) content, as quantified by 1 H-magnetic resonance
spectroscopy ( 1 H-MRS), is associated with reduced insulin sensitivity. At present, it is unclear
which factors determine IMCL formation and how rapidly IMCL accumulation can be ... Cited by 158 - Related articles - BL Direct - All 5 versions
K Brechtel, DB Dahl, J Machann, OP … - Magnetic …, 2001 - interscience.wiley.com The influence of a short-term elevation of free fatty acids (FFAs) on intramyocellular lipids
(IMCL) under hyperinsulinemic conditions was monitored in five healthy male subjects in the
course of a 5-hr hyperinsulinemic glucose clamp. During the glucose clamp a lipid ... Cited by 74 - Related articles - BL Direct - All 4 versions
M Krssak, K Falk Petersen, A Dresner, L DiPietro, SM … - Diabetologia, 1999 - Springer Skeletal muscle insulin resistance is a common fea- ture of obesity, dyslipidaemia and arterial
hyperten- sion, and it is an important predisposing factor for Type II (non-insulin-dependent)
diabetes mellitus and premature cardiovascular disease [1]. Evidence has been provided ... Cited by 558 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org G Boden, B Lebed, M Schatz, C Homko, S Lemieux - Diabetes, 2001 - Am Diabetes Assoc The reason for the 3- to 4-h delay between a rise in plasma free fatty acid (FFA) levels and the
development of insulin resistance remains unknown. In the current study, we have tested the
hypothesis that the delay may be caused by the need for plasma FFAs to first enter ... Cited by 286 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] G Perseghin, P Scifo, F De Cobelli, E Pagliato, A … - Diabetes, 1999 - Am Diabetes Assoc Determinant of in Vivo Insulin Resistance in Humans ... A 1 H - 1 3 C Nuclear Magnetic Resonance
Spectroscopy ... Assessment in Offspring of Type 2 Diabetic Parents ... Gianluca Perseghin,
Paola Scifo, Francesco De Cobelli, Emanuela Pagliato, Alberto Battezzati, Cinzia ... Cited by 436 - Related articles - BL Direct - All 4 versions
- ►endojournals.org C Thamer, J Machann, O Bachmann, M Haap, … - Journal of Clinical …, 2003 - Endocrine Soc The existence of metabolically relevant intramyocellular lipids (IMCL) as assessed by the noninvasive
1 H-magnetic resonance spectroscopy (MRS) has been established. In the present studies, we
analyzed the relationships between IMCL in two muscle types [the predominantly ... Cited by 102 - Related articles - BL Direct - All 4 versions
L Ryysy, AM Hakkinen, T Goto, S … - DIABETES-NEW …, 2000 - Am Diabetes Assoc Page 1. DIABETES, VOL. 49, MAY 2000 749 Hepatic Fat Content and Insulin Action on Free
Fatty Acids and Glucose Metabolism Rather Than Insulin Absorption Are Associated With Insulin
Requirements During Insulin Therapy in Type 2 Diabetic Patients ... Cited by 210 - Related articles - BL Direct - All 7 versions
R Sinha, S Dufour, KF Petersen, V LeBon, S Enoksson, … - Diabetes, 2002 - Am Diabetes Assoc The metabolism and composition of skeletal muscle tissue is of special interest because it is
a primary site of insulin action and plays a key role in the pathogenesis of insulin resistance.
Intramyocellular (IMCL) triglyceride stores are an accessible form of energy that may ... Cited by 191 - Related articles - BL Direct - All 5 versions
