DQ Shih, S Screenan, KN Munoz, L Philipson, … - Diabetes, 2001 - Am Diabetes Assoc Mutations in hepatocyte nuclear factor 1α (HNF-1α) lead to maturity-onset
diabetes of the young type 3 as a result of impaired insulin secretory response
in pancreatic β-cells. The expression of 50 genes essential for normal ... Cited by 142 - Related articles - BL Direct - All 5 versions
ID Dukes, S Sreenan, MW Roe, M Levisetti, YP … - Journal of Biological Chemistry, 1998 - ASBMB Mutations in the hepatocyte nuclear factor-1α (HNF-1α) gene cause maturity
onset diabetes of the young type 3, a form of type 2 diabetes mellitus. In mice
lacking the HNF-1α gene, insulin secretion and intracellular calcium ([Ca ... Cited by 122 - Related articles - BL Direct - All 6 versions
- ►nih.gov SF Boj, M Párrizas, MA Maestro, J Ferrer - Proceedings of the National Academy of Sciences of …, 2001 - National Acad Sciences Mutations in the human genes encoding hepatocyte nuclear factors (HNF) 1α, 1β,
4α, and IPF1(PDX1/IDX1/STF1) result in pancreatic β cell dysfunction and
diabetes mellitus. In hepatocytes, hnf4α controls the transcription of ... Cited by 161 - Related articles - BL Direct - All 8 versions
H Wang, PA Antinozzi, KA Hagenfeldt, P … - The EMBO Journal, 2000 - pubmedcentral.nih.gov The reverse tetracycline-dependent transactivator system was employed in
insulinoma INS-1 cells to achieve controlled inducible expression of hepatocyte
nuclear factor-1α (HNF1α)-P291fsinsC, the most common mutation associated ... Cited by 81 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] H Wang, P Maechler, KA Hagenfeldt, CB … - The EMBO Journal, 1998 - pubmedcentral.nih.gov The EMBO Journal Vol.17 No.22 pp.6701–6713, 1998 ... Dominant-negative
suppression of HNF-1α function results in defective insulin gene transcription
and ... Haiyan Wang, Pierre Maechler, Kerstin A.Hagenfeldt and Claes B. ... Cited by 122 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org H Thomas, K Jaschkowitz, M Bulman, TM … - Human molecular genetics, 2001 - Oxford Univ Press Maturity-onset diabetes of the young (MODY) is a monogenic, autosomal dominant
subtype of early-onset diabetes mellitus due to defective insulin secretion by
the pancreatic ß-cell in humans. Five different genes have been identified ... Cited by 155 - Related articles - BL Direct - All 6 versions
- ►endojournals.org KA Hagenfeldt-Johansson, PL Herrera, H Wang … - Endocrinology, 2001 - Endocrine Soc Mutations in the transcription factor hepatocyte nuclear factor-1 (HNF-1 ) cause
maturity-onset diabetes of the young 3, a severe form of diabetes characterized
by pancreatic ß-cell dysfunction. We have used targeted expression of a ... Cited by 40 - Related articles - BL Direct - All 2 versions
- ►nih.gov YH Lee, B Sauer, FJ Gonzalez - Molecular and Cellular Biology, 1998 - Am Soc Microbiol Mice deficient in hepatocyte nuclear factor 1 alpha (HNF-1 ) were produced by
use of the Cre-loxP recombination system. HNF-1 -null mice are viable but
sterile and exhibit a phenotype reminiscent of both Laron-type dwarfism and ... Cited by 192 - Related articles - BL Direct - All 4 versions
K Yamagata, T Nammo, M Moriwaki, A Ihara, K … - Diabetes, 2002 - Am Diabetes Assoc One subtype of maturity-onset diabetes of the young (MODY)-3 results from
mutations in the gene encoding hepatocyte nuclear factor (HNF)-1α. We generated
transgenic mice expressing a naturally occurring dominant-negative form of ... Cited by 65 - Related articles - BL Direct - All 4 versions
