F Wang, RL Hull, J Vidal, M Cnop, SE Kahn - Diabetes, 2001 - Am Diabetes Assoc Islet amyloid occurs in >90% of type 2 diabetic patients and may play a role in the pathogenesis
of this disease. To determine whether islet amyloid occurs diffusely throughout the pancreas,
whether it affects islets equally, and whether it decreases islet endocrine cells, we ... Cited by 40 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org RL Hull, S Andrikopoulos, CB Verchere, J Vidal, F … - Diabetes, 2003 - Am Diabetes Assoc Transgenic mice expressing the amyloidogenic human islet amyloid polypeptide (hIAPP) in their
islet β-cells are a model of islet amyloid formation as it occurs in type 2 diabetes. Our hIAPP transgenic
mice developed islet amyloid when fed a breeder chow but not regular chow. Because ... Cited by 37 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org [PDF] S Andrikopoulos, CB Verchere, Y Terauchi, T … - Diabetes, 2000 - Am Diabetes Assoc Type 2 diabetes is characterized by impaired -cell function, hyperglycemia, and islet amyloid
deposition. The primary constituent of islet amyloid is the 37–amino acid -cell product called
islet amyloid polypeptide (IAPP) or amylin. To study mechanisms of islet amyloid ... Cited by 23 - Related articles - BL Direct - All 4 versions
SE Kahn, S Andrikopoulos, CB Verchere, F Wang, RL … - Diabetologia, 2000 - Springer Amyloid is present in over 85% of human subjects with Type II (non-insulin-dependent) diabetes
melli- tus [1] with islet amyloid polypeptide (IAPP or amy- lin) being its unique component [2,
3]. The amyloido- genic sequence in the mid-portion of the IAPP mole- Cited by 13 - Related articles - BL Direct - All 4 versions
DA D'Alessio, CB Verchere, SE Kahn, V Hoagland, DG … - Diabetes, 1994 - Am Diabetes Assoc Islet amyloid polypeptide (IAPP) is a secretory product of the pancreatic beta-cell, which is the
primary constituent of the islet amyloid that develops in type II diabetes. To study the role the
inherent amyloidogenicity of human IAPP (hIAPP) plays in the formation of islet amyloid ... Cited by 52 - Related articles - BL Direct - All 5 versions
P Westermark - Upsala journal of medical sciences, 1972 - ncbi.nlm.nih.gov 1: Ups J Med Sci. 1972;77(2):91-4. Quantitative studies on amyloid in the islets of Langerhans.
Westermark P. Mesh Terms: Amyloid/analysis*; Amyloidosis/etiology; Amyloidosis/pathology*;
Autopsy; Diabetes Complications; Diabetes Mellitus/pathology; ... Cited by 57 - Related articles
DLA MacArthur, EJP De Koning, JS Verbeek, JF Morris, … - Diabetologia, 1999 - Springer Amyloid deposits are found in the islets of Langer- hans of up to 96% of patients with Type II
(non-insu- lin-dependent) diabetes mellitus [1, 2] but the rela- ... Amyloid fibril formation is progressive
and correlates with beta-cell ... DLA MacArthur 1 , EJP de Koning 1 , JSVerbeek 2 , JF ... Cited by 17 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] WC Soeller, J Janson, SE Hart, JC Parker, MD Carty, … - Diabetes, 1998 - Am Diabetes Assoc We have previously shown that hemizygous transgenic mice expressing human islet amyloid
polypeptide (hIAPP) in pancreatic -cells have no diabetic pheno- type, whereas in the homozygous
state, they developed severe, early-onset hyperglycemia associated with impaired insulin ... Cited by 94 - Related articles - BL Direct - All 6 versions
JWM Höppener, C Oosterwijk, MG Nieuwenhuis, G … - Diabetologia, 1999 - Springer Type II (non-insulin-dependent) diabetes mellitus is a common, age-related, multifactorial disease
[1, 2]. Although still debated, it seems that the primary de- fect in most subjects developing Type
II diabetes in- volves resistance to insulin action in muscle or liver or in both which initially ... Cited by 90 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] GT Westermark, S Gebre-Medhin, DF Steiner, … - Molecular …, 2000 - pubmedcentral.nih.gov Islet amyloid polypeptide (IAPP, amylin) is a regulatory peptide, expressed by pancreatic islet
beta cells and stored and released together with insulin (1). The normal function of IAPP is insufficiently
understood but experimentally many different effects have been described Cited by 32 - Related articles - BL Direct - All 6 versions
