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Scholar Results 1 - 10 of about 101 related to Larsen: Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting.... (0.12 sec) 

Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and …

- diabetesjournals.org
PJ Larsen, C Fledelius, LB Knudsen, M Tang- … - Diabetes, 2001 - Am Diabetes Assoc
Postprandial release of the incretin glucagon-like peptide-1 (GLP-1) has been
suggested to act as an endogenous satiety factor in humans. In rats, however,
the evidence for this is equivocal probably because of very high endogenous ...
Cited by 101 - Related articles - BL Direct - All 4 versions

NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose …


U Ribel, MO Larsen, B Rolin, RD Carr, M … - European journal of pharmacology, 2002 - Elsevier
Glucagon-like peptide-1 (GLP-1) is an effective anti-diabetic agent, but its
metabolic instability makes it therapeutically unsuitable. This study
investigated the pharmacodynamics of a long-acting GLP-1 derivative ...
Cited by 43 - Related articles - All 4 versions

The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell …

- physiology.org
B Rolin, MO Larsen, CF Gotfredsen, CF … - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc
NN2211 is a long-acting, metabolically stable glucagon-like peptide-1 (GLP-1)
derivative designed for once daily administration in humans. NN2211 dose
dependently reduced the glycemic levels in ob/ob mice, with ...
Cited by 129 - Related articles - BL Direct - All 4 versions

Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or …

- endojournals.org
K Meeran, D O'Shea, CMB Edwards, MD Turton, … - Endocrinology, 1999 - Endocrine Soc
Central nervous system glucagon-like peptide-1-(7–36) amide (GLP-1)
administration has been reported to acutely reduce food intake in the rat. We
here report that repeated intracerebroventricular (icv) injection of GLP-1 ...
Cited by 136 - Related articles - BL Direct - All 4 versions

Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats

- endojournals.org
M Szayna, ME Doyle, JA Betkey, HW … - Endocrinology, 2000 - Endocrine Soc
Exendin-4 is a 39 amino acid peptide produced in the salivary gland of the Gila
monster lizard. It has a 53% amino acid homology to the incretin hormone
glucagon-like peptide-1 (GLP-1). Exendin-4 induces insulin release through ...
Cited by 195 - Related articles - BL Direct - All 2 versions

The GLP-1 derivative NN2211 restores β-cell sensitivity to glucose in type 2 diabetic patients …


AM Chang, G Jakobsen, J Sturis, MJ Smith, CJ … - Diabetes, 2003 - Am Diabetes Assoc
Glucagon-like peptide 1 (GLP-1) stimulates insulin secretion in a
glucose-dependent manner, but its short half-life limits its therapeutic
potential. We tested NN2211, a long-acting GLP-1 derivative, in 10 subjects ...
Cited by 94 - Related articles - BL Direct - All 9 versions

Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces …


CB Juhl, M Hollingdal, J Sturis, G Jakobsen, H … - Diabetes, 2002 - Am Diabetes Assoc
Glucagon-like peptide 1 (GLP-1) is a potent glucose-lowering agent of potential
interest for the treatment of type 2 diabetes. To evaluate actions of NN2211, a
long-acting GLP-1 derivative, we examined 11 patients with type 2 diabetes, ...
Cited by 174 - Related articles - BL Direct - All 6 versions

Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food …


HR Davis Jr, DE Mullins, JM Pines, LM Hoos, … - Obesity research, 1998 - ncbi.nlm.nih.gov
Glucagon-like peptide (7-36) amide (GLP-1) acutely inhibits food and water
consumption in rats after intracerebroventricular (icv) administration. To
assess the potential for desensitization of these effects, we investigated ...
Cited by 29 - Related articles - BL Direct - All 2 versions

Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats


M Tang-Christensen, PJ Larsen, R Goke, A … - … Journal of Physiology- Regulatory, Integrative and …, 1996 - Am Physiological Soc
34 other HighWire hosted articles, the first 5 are: This article has been cited
by ... [PDF] [Full Text] [Abstract] , February 1, 2005; 288 (2): E447-E453. Am
J Physiol Endocrinol Metab AD Strader, TP Vahl, RJ Jandacek, SC Woods, DA D' ...
Cited by 235 - Related articles - BL Direct - All 3 versions

Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy …

- physiology.org
CMB Edwards, SA Stanley, R Davis, AE Brynes … - American Journal of Physiology- Endocrinology And …, 2001 - Am Physiological Soc
Exendin-4 is a long-acting potent agonist of the glucagon-like peptide 1 (GLP-1)
receptor and may be useful in the treatment of type 2 diabetes and obesity. We
examined the effects of an intravenous infusion of exendin-4 (0.05 pmol · ...
Cited by 230 - Related articles - BL Direct - All 4 versions


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