T Teruel, R Hernandez, M Lorenzo - Diabetes, 2001 - Am Diabetes Assoc Tumor necrosis factor (TNF)-α causes insulin resistance on glucose uptake in
fetal brown adipocytes. We explored the hypothesis that some effects of TNF-α
could be mediated by the generation of ceramide, given that TNF-α ... Cited by 81 - Related articles - BL Direct - All 4 versions
E Hajduch, A Balendran, IH Batty, GJ … - Diabetologia, 2001 - Springer The activation of phosphoinositide 3-kinase (PI3K) by insulin represents a key
signalling event in the hormonal stimulation of diverse cellular responses ...
Ceramide impairs the insulin-dependent membrane recruitment Cited by 91 - Related articles - BL Direct - All 3 versions
R Hernandez, T Teruel, M Lorenzo - FEBS letters, 2001 - Elsevier Insulin acutely stimulated glucose uptake in rat primary brown adipocytes in a
PI3-kinase-dependent but p70S6-kinase-independent manner. Since Akt represents
an intermediate step between these kinases, this study investigated the ... Cited by 53 - Related articles - All 4 versions
M Straczkowski, I Kowalska, A Nikolajuk, S … - Diabetes, 2004 - Am Diabetes Assoc In vitro studies revealed that insulin resistance might be associated with the
intracellular formation of ceramide, the second messenger in the sphingomyelin
signaling pathway. The aim of the present study was to examine the content ... Cited by 69 - Related articles - BL Direct - All 5 versions
MJ Zinda, CJ Vlahos, MT Lai - Biochemical and Biophysical Research …, 2001 - Elsevier In the present study, treatment of the PTEN negative U87MG human glioblastoma
cell line with C2-ceramide resulted in a dose- and time-dependent decrease in
the constitutive phosphorylation of Akt at threonine 308 and serine 473. ... Cited by 38 - Related articles - BL Direct - All 6 versions
- ►jbc.org S Stratford, KL Hoehn, F Liu, SA Summers - Journal of Biological Chemistry, 2004 - ASBMB The sphingolipid ceramide negatively regulates insulin action by inhibiting
Akt/protein kinase B (PKB), a serine/threonine kinase that is a central
regulator of glucose uptake and anabolic metabolism. Despite considerable ... Cited by 69 - Related articles - BL Direct - All 4 versions
R Hernandez, T Teruel, M Lorenzo - Diabetologia, 2003 - Springer Aims/hypothesis. Rosiglitazone is used to treat Type 2 diabetes because it
improves insulin sensitivity. How- ever, the specific molecular mechanism by
which this compound acts has not yet been explained. Methods. We used fetal ... Cited by 20 - Related articles - BL Direct - All 3 versions
R Cazzolli, L Carpenter, TJ Biden, C Schmitz- … - Diabetes, 2001 - Am Diabetes Assoc We have shown previously that palmitate treatment of C2C12 skeletal muscle
myotubes causes inhibition of the protein kinase B (PKB) pathway and hence
reduces insulin-stimulated glycogen synthesis through the elevation of ... Cited by 87 - Related articles - BL Direct - All 5 versions
CN Wang, L O'Brien, DN Brindley - Diabetes, 1998 - Am Diabetes Assoc Incubation of 3T3-L1 adipocytes with C2- and C6-ceramides (N-acetyl- and
N-hexanoylsphingosines) but not dihydro-C2-ceramide increased 2-deoxyglucose
uptake in the absence of insulin. This effect was inhibited by PD 98059, LY ... Cited by 73 - Related articles - BL Direct - All 5 versions
- ►jbc.org JA Chavez, TA Knotts, LP Wang, G Li, RT … - Journal of Biological Chemistry, 2003 - ASBMB Multiple studies suggest that lipid oversupply to skeletal muscle contributes to
the development of insulin resistance, perhaps by promoting the accumulation of
lipid metabolites capable of inhibiting signal transduction. Herein we ... Cited by 156 - Related articles - BL Direct - All 5 versions
