W Pratipanawatr, T Pratipanawatr, K Cusi, R Berria, JM … - Diabetes, 2001 - Am Diabetes Assoc Normoglycemic subjects with a strong family history of type 2 diabetes are insulin resistant, but
the mechanism of insulin resistance in skeletal muscle of such individuals is unknown. The present
study was undertaken to determine whether abnormalities in insulin-signaling events are ... Cited by 62 - Related articles - BL Direct - All 4 versions
M Meyer, K Levin, T Grimmsmann, H Beck-Nielsen, H … - Diabetologia, 2002 - Springer Aims/hypothesis. Alterations in insulin signalling could contribute to insulin resistance in Type
II (non-insulin- dependent) diabetes mellitus. Some of these alterations could be secondary to
the diabetic state, ie. the hyper- glycaemia or increased NEFA concentrations. We sought ... Cited by 34 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org [PDF] S Jackson, SM Bagstaff, S Lynn, SJ Yeaman, DM … - Diabetes, 2000 - Am Diabetes Assoc To investigate the contribution of inherited biochemical defects to the peripheral insulin resistance
of type 2 dia- betes, we studied cultured skeletal muscle from 10 insulin-resistant nondiabetic
first-degree relatives of type 2 diabetic families and 6 control subjects. Insulin stimulation ... Cited by 35 - Related articles - BL Direct - All 4 versions
H Storgaard, XM Song, CB Jensen, S Madsbad, M … - Diabetes, 2001 - Am Diabetes Assoc To determine whether defects in the insulin signal transduction cascade are present in skeletal
muscle from prediabetic individuals, we excised biopsies from eight glucose-intolerant male
first-degree relatives of patients with type 2 diabetes (IGT relatives) and nine matched ... Cited by 55 - Related articles - BL Direct - All 5 versions
- ►endojournals.org H Storgaard, CB Jensen, M Bjornholm, XM … - Journal of Clinical …, 2004 - Endocrine Soc Insulin-stimulated glucose disposal decreased approximately 25% after short- and long-term
fat infusion in both IGT relatives and controls. Glucose oxidation decreased and lipid oxidation
increased after both short- and long-term fat infusion in both groups. Insulin-stimulated ... Cited by 23 - Related articles - BL Direct - All 6 versions
A Carpentier, SD Mittelman, RN Bergman, A Giacca, … - Diabetes, 2000 - Am Diabetes Assoc Our recent in vivo observations in healthy nonobese humans have demonstrated that prolonged
elevation of plasma free fatty acids (FFAs) results in diminished glucose-stimulated insulin secretion
(GSIS) when the F FA-mediated decrease in insulin sensitivity is taken into account. In the ... Cited by 94 - Related articles - BL Direct - All 5 versions
- ►nih.gov K Cusi, K Maezono, A Osman, M … - Journal of Clinical …, 2000 - Am Soc Clin Investig The broad nature of insulin resistant glucose metabolism in skeletal muscle of patients with type
2 diabetes suggests a defect in the proximal part of the insulin signaling network. We sought
to identify the pathways compromised in insulin resistance and to test the effect of ... Cited by 507 - Related articles - BL Direct - All 6 versions
A Krook, M Bjornholm, D Galuska, XJ Jiang, … - DIABETES-NEW …, 2000 - Am Diabetes Assoc We characterized metabolic and mitogenic signaling pathways in isolated skeletal muscle from
well-matched type 2 diabetic and control subjects. Time course studies of the insulin
receptor, insulin receptor substrate ( IRS )-1/2, and phosphatidylinositol (PI) 3-kinase ... Cited by 209 - Related articles - BL Direct - All 4 versions
