- ►diabetesjournals.org J Spranger, M Osterhoff, M Reimann, M Möhlig, M … - Diabetes, 2001 - Am Diabetes Assoc Retinal neovascularization characterizes proliferative diabetic retinopathy (PDR). Pigment
epithelium-derived factor (PEDF) has been shown to be a major antiangiogenic growth factor
in the mammalian eye. PEDF expression is suppressed by hypoxia, and changes in ... Cited by 167 - Related articles - BL Direct - All 7 versions
N Ogata, J Tombran-Tink, M Nishikawa, T … - American journal of …, 2001 - Elsevier RESULTS: The vitreal concentration of pigment epithelium-derived factor was 1.15 ± 0.23
μg/ml (mean ± standard error) in eyes with diabetic retinopathy, 3.28 ± 0.69 μg/ml in rhegmatogenous
retinal detachment, and 1.71 ± 0.39 μg/ml in idiopathic macular hole. The pigment ... Cited by 94 - Related articles - BL Direct - All 11 versions
- ►iovs.org EJ Duh, HS Yang, I Suzuma, M Miyagi, E Youngman, … - … ophthalmology & visual …, 2002 - ARVO METHODS. Human recombinant PEDF was expressed in the human embryonic kidney 293 cell
line and purified by ammonium sulfate precipitation and cation exchange chromatography.
C57BL/6 mice were exposed to 75% oxygen from postnatal day (P)7 to P12 and then ... Cited by 192 - Related articles - BL Direct - All 7 versions
J Spranger, M Osterhoff, M Reimann, M Möhlig, M … - DIABETES, 2001 - Am Diabetes Assoc Page 1. Rapid Publication Loss of the Antiangiogenic Pigment Epithelium-Derived Factor
in Patients With Angiogenic Eye Disease Joachim Spranger, 1,2 Martin Osterhoff, 1,2
Manja Reimann, 1,2 Matthias Möhlig, 1,2 Michael Ristow, 1,2 ... Related articles
N Ogata, M Nishikawa, T Nishimura, Y Mitsuma, M … - American journal of …, 2002 - Elsevier PURPOSE: To determine the levels of pigment epithelium-derived factor (PEDF) and vascular
endothelial growth factor (VEGF) in the vitreous of patients with diabetic retinopathy (DR). ...
DESIGN: Experimental study of PEDF and VEGF levels in vitreous samples collected ... Cited by 135 - Related articles - All 15 versions
V Stellmach, SE Crawford, W Zhou, N … - Proceedings of the …, 2001 - National Acad Sciences Aberrant blood vessel growth in the retina that underlies the pathology of proliferative diabetic
retinopathy and retinopathy of prematurity is the result of the ischemia-driven disruption of the
normally antiangiogenic environment of the retina. In this study, we show that a potent ... Cited by 290 - Related articles - BL Direct - All 7 versions
G Gao, Y Li, D Zhang, S Gee, C Crosson, J Ma - FEBS letters, 2001 - Elsevier Retinal levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor
(PEDF), an angiogenic inhibitor, were measured and correlated with the ischemia-induced retinal
neovascularization in rats. The retinas with neovascularization showed a 5-fold increase ... Cited by 167 - Related articles - All 5 versions
NM Holekamp, N Bouck, O Volpert - American journal of ophthalmology, 2002 - Elsevier RESULTS: In vitreous samples from nine eyes with CNV due to AMD the mean ± SD PEDF level
was 2.8 ng/μl ± 1.3 ng/μl. In vitreous samples from 12 age-matched control eyes the mean ±
SD PEDF level was 16.4 ng/μl ± 7.1 ng/μl. The difference between the two groups was ... Cited by 128 - Related articles - All 10 versions
DW Dawson, OV Volpert, P Gillis, SE Crawford, HJ Xu, … - Science, 1999 - sciencemag.org In the absence of disease, the vasculature of the mammalian eye is quiescent, in part because
of the action of angiogenic inhibitors that prevent vessels from invading the cornea and
vitreous. Here, an inhibitor responsible for the avascularity of these ocular compartments ... Cited by 774 - Related articles - BL Direct - All 9 versions
