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Scholar Results 1 - 10 of about 101 related to García-Ocaña: Transgenic overexpression of hepatocyte growth factor in the β-cell markedly.... (0.14 sec) 

Transgenic overexpression of hepatocyte growth factor in the β-cell markedly improves islet …


A García-Ocaña, RC Vasavada, A Cebrian, V … - Diabetes, 2001 - Am Diabetes Assoc
Recent advances in human islet transplantation have highlighted the need for
expanding the pool of ß-cells available for transplantation. We have developed
three transgenic models in which growth factors (hepatocyte growth factor ...
Cited by 80 - Related articles - BL Direct - All 4 versions

[PDF] Transgenic Overexpression of Hepatocyte Growth Factor in the-Cell Markedly Improves Islet …


A Garcıáa, RC Vasavada, A Cebrian, V Reddy … - Diabetes, 2001 - Am Diabetes Assoc
Recent advances in human islet transplantation have highlighted the need for
expanding the pool of -cells available for transplantation. We have developed
three transgenic models in which growth factors (hepatocyte growth factor ...
Cited by 2 - Related articles

Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell …

- jbc.org
A Garcia-Ocana, KK Takane, MA Syed, WM … - Journal of Biological Chemistry, 2000 - ASBMB
Hepatocyte growth factor (HGF) is produced in pancreatic mesenchyme-derived
cells and in islet cells. In vitro, HGF increases the insulin content and
proliferation of islets. To study the role of HGF in the islet in vivo, we ...
Cited by 135 - Related articles - BL Direct - All 4 versions

Targeted expression of placental lactogen in the beta cells of transgenic mice results in …

- jbc.org
RC Vasavada, A Garcia-Ocana, WS Zawalich, … - Journal of Biological Chemistry, 2000 - ASBMB
The factors that regulate pancreatic beta cell proliferation are not well
defined. In order to explore the role of murine placental lactogen (PL)-I
(mPL-I) in islet mass regulation in vivo, we developed transgenic mice in ...
Cited by 86 - Related articles - BL Direct - All 4 versions

Hepatocyte growth factor stimulates proliferation of pancreatic beta-cells particularly in …

- endocrinology-journals.org [PDF] 
S Gahr, M Merger, LC Bollheimer, CG … - Journal of molecular endocrinology, 2002 - Soc Endocrinology
We investigated the role of hepatocyte growth factor (HGF) in β-cell growth and
its complex intracellular signal transduction pathways. Cell proliferation was
measured in the β-cell line INS-1 using [3H]thymidine incorporation. ...
Cited by 35 - Related articles - BL Direct - All 8 versions

Overexpression of parathyroid hormone-related protein inhibits pancreatic β-cell death in …

- diabetesjournals.org
A Cebrian, A García-Ocaña, KK Takane, D … - Diabetes, 2002 - Am Diabetes Assoc
Pancreatic β-cell survival is critical in the setting of diabetes as well as in
islet transplantation. Transgenic mice overexpressing parathyroid
hormone-related protein (PTHrP) targeted to β-cells using the rat insulin ...
Cited by 37 - Related articles - BL Direct - All 4 versions

A role for hepatocyte growth factor/scatter factor in fetal mesenchyme-induced pancreatic …


T Otonkoski, V Cirulli, M Beattie, MI Mally, G … - Endocrinology, 1996 - Endocrine Soc
Page 1. 0013.7227/96/$03 00/O Endocrinology CopyrIght 6 1996 by The Endocrine
Society A Role for Hepatocyte Growth Factor/Scatter Factor in ...
Cited by 103 - Related articles - BL Direct - All 5 versions

Characterization of mice doubly transgenic for parathyroid hormone-related protein and …


Y Fujinaka, D Sipula, A Garcia-Ocaña, RC … - Diabetes, 2004 - Am Diabetes Assoc
Transgenic overexpression of either parathyroid hormone-related peptide (PTHrP)
or mouse placental lactogen type 1 (mPL1) in pancreatic β-cells, using the rat
insulin II promoter (RIP), results in islet hyperplasia either through ...
Cited by 27 - Related articles - BL Direct - All 5 versions

Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves …

- jbc.org
A Garcia-Ocana, KK Takane, VT Reddy, JC … - Journal of Biological Chemistry, 2003 - ASBMB
Hepatocyte growth factor (HGF) increases beta cell proliferation and function in
rat insulin promoter (RIP)-targeted transgenic mice. RIP-HGF mouse islets also
function superiorly to normal islets in a transplant setting. Here, we ...
Cited by 55 - Related articles - BL Direct - All 5 versions

Targeted inactivation of hepatocyte growth factor receptor c-met in β-cells leads to …

- diabetesjournals.org
J Roccisana, V Reddy, RC Vasavada, JA … - Diabetes, 2005 - Am Diabetes Assoc
Overexpression of hepatocyte growth factor (HGF) in the ß-cell of transgenic
mice enhances ß-cell proliferation, survival, and function. In the current
studies, we have used conditional ablation of the c-met gene to uncover the ...
Cited by 31 - Related articles - All 6 versions


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