H Storgaard, XM Song, CB Jensen, S Madsbad, M … - Diabetes, 2001 - Am Diabetes Assoc To determine whether defects in the insulin signal transduction cascade are present in skeletal
muscle from prediabetic individuals, we excised biopsies from eight glucose-intolerant male
first-degree relatives of patients with type 2 diabetes (IGT relatives) and nine matched ... Cited by 55 - Related articles - BL Direct - All 5 versions
M Meyer, K Levin, T Grimmsmann, H Beck-Nielsen, H … - Diabetologia, 2002 - Springer Aims/hypothesis. Alterations in insulin signalling could contribute to insulin resistance in Type
II (non-insulin- dependent) diabetes mellitus. Some of these alterations could be secondary to
the diabetic state, ie. the hyper- glycaemia or increased NEFA concentrations. We sought ... Cited by 34 - Related articles - BL Direct - All 3 versions
W Pratipanawatr, T Pratipanawatr, K Cusi, R Berria, JM … - Diabetes, 2001 - Am Diabetes Assoc Normoglycemic subjects with a strong family history of type 2 diabetes are insulin resistant, but
the mechanism of insulin resistance in skeletal muscle of such individuals is unknown. The present
study was undertaken to determine whether abnormalities in insulin-signaling events are ... Cited by 62 - Related articles - BL Direct - All 4 versions
J Krutzfeldt, C Kausch, A Volk, HH Klein, K … - DIABETES-NEW …, 2000 - Am Diabetes Assoc Insulin Signaling and Action in Cultured Skeletal ... Muscle Cells From Lean Healthy Humans
With High ... Jan Krützfeldt, Christiana Kausch, Annette Volk, Harald H. Klein, Kristian Rett,
Hans-U. Häring, and Michael Stumvoll ... The aim of these studies was to investigate ... Cited by 45 - Related articles - BL Direct - All 4 versions
K Højlund, P Stæhr, BF Hansen, KA Green, DG Hardie, … - Diabetes, 2003 - Am Diabetes Assoc In type 2 diabetes, insulin activation of muscle glycogen synthase (GS) is impaired. This defect
plays a major role for the development of insulin resistance and hyperglycemia. In animal
muscle, insulin activates GS by reducing phosphorylation at both NH 2 - and ... Cited by 59 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] A Krook, RA Roth, XJ Jiang, JR Zierath, H Wallberg- … - Diabetes, 1998 - Am Diabetes Assoc The serine/threonine kinase Akt (PKB/Rac) has been implicated as playing a role in the
insulin-signaling pathway to glucose transport. Little is known regarding the regulation of Akt
kinase activity in insulin-sensitive tissues, such as skeletal muscle, or whether this regu- ... Cited by 216 - Related articles - BL Direct - All 4 versions
- ►nih.gov YB Kim, SE Nikoulina, TP Ciaraldi, RR … - Journal of Clinical …, 1999 - Am Soc Clin Investig To determine whether the serine/threonine kinase Akt (also known as protein kinase B) is activated
in vivo by insulin administration in humans, and whether impaired activation of Akt could play
a role in insulin resistance, we measured the activity and phosphorylation of Akt isoforms ... Cited by 262 - Related articles - BL Direct - All 10 versions
P Damsbo, A Vaag, O Hother-Nielsen, H Beck-Nielsen - Diabetologia, 1991 - Springer Summary. In order to evaluate the importance of a defect in insulin mediated non-oxidative glucose
metabolism and gly- cogen synthase activity in skeletal muscles in obese subjects with and without
Type 2 (non-insulin-dependent) diabetes mellitus we studied: 10 lean and 10 obese ... Cited by 126 - Related articles - All 3 versions
JF Wojtaszewski, BF Hansen, B Kiens, EA Richter - Diabetes, 1997 - Am Diabetes Assoc Activation of early steps in the insulin signaling cascade in human skeletal muscle was investigated
using a one-step euglycemic-hyperinsulinemic (approximately 100 pU/ml) clamp in seven healthy
young men 3 h after one-legged exercise. Concomitant insulin stimulation (three- to ... Cited by 107 - Related articles - BL Direct - All 6 versions
M Gaster, I Petersen, K Højlund, P Poulsen, H Beck- … - Diabetes, 2002 - Am Diabetes Assoc The most well-described defect in the pathophysiology of type 2 diabetes is reduced insulin-mediated
glycogen synthesis in skeletal muscles. It is unclear whether this defect is primary or acquired
secondary to dyslipidemia, hyperinsulinemia, or hyperglycemia. We determined the ... Cited by 50 - Related articles - BL Direct - All 4 versions
