- ►diabetesjournals.org LA Blair, MR Heitmeier, AL Scarim, LB Maggi, JA … - Diabetes, 2001 - Am Diabetes Assoc Environmental factors, such as viral infection, have been implicated in the destruction of β-cells
during the development of autoimmune diabetes. Double-stranded RNA (dsRNA), produced
during viral replication, is an active component of a viral infection that stimulates antiviral ... Cited by 17 - Related articles - BL Direct - All 5 versions
MR Heitmeier, AL Scarim, JA Corbett - Journal of Biological Chemistry, 1999 - ASBMB Viral infection has been implicated as a triggering event that may initiate β-cell damage during
the development of autoimmune diabetes. In this study, the effects of the viral replicative
intermediate, double-stranded RNA (dsRNA) (in the form of synthetic polyinosinic- ... Cited by 29 - Related articles - BL Direct - All 6 versions
- ►amjpathol.org AL Scarim, M Arnush, LA Blair, J Concepcion, MR … - American Journal of …, 2001 - ASIP Viral infection is one environmental factor that has been implicated as a precipitating event that
may initiate ß-cell damage during the development of diabetes. This study examines the mechanisms
by which the viral replicative intermediate, double-stranded (ds) RNA impairs ß-cell ... Cited by 33 - Related articles - BL Direct - All 6 versions
[CITATION] Mechanisms of-cell death in response to double-stranded (ds) RNA and interferon- …
LB Maggi Jr, MR Heitmeier, D Scheuner, RJ … - The EMBO …, 2000 - pubmedcentral.nih.gov In this study, the role of the double-stranded (ds) RNA-dependent protein kinase (PKR) in macrophage
activation was examined. dsRNA [polyinosinic:polycytidylic acid (poly IC)]-stimulated inducible
nitric oxide synthase, interleukin (IL)-1α and IL-1β mRNA expression, nitrite formation and ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►jbc.org LA Blair, LB Maggi Jr, AL Scarim, JA Corbett - Journal of Biological Chemistry, 2002 - ASBMB Environmental factors, such as viral infection, have been implicated as potential triggering events
leading to the initial destruction of pancreatic cells during the development of autoimmune
diabetes. Double-stranded RNA (dsRNA), the active component of a viral infection that ... Cited by 27 - Related articles - BL Direct - All 4 versions
V BONNEVIE-NIELSEN, AM GERDES, JAN … - Journal of interferon …, 1991 - liebertonline.com Page 1. JOURNAL OF INTERFERON RESEARCH 11:255-260 (1991) Mary Ann Liebert,
Inc., Publishers Interferon Stimulates the Expression of 2',5'-01igoadenylate Synthetase
and MHC Class I Antigens in Insulin-Producing Cells ... Cited by 5 - Related articles - All 3 versions
CH Ewel, DO Sobel, BJ Zeligs, JA Bellanti - Diabetes, 1992 - Am Diabetes Assoc We developed a new experimental model of accelerated diabetes mellitus in the genetically
susceptible diabetes-prone BB rat with the administration of the IFN-alpha inducer poly I:C. With
this model, there was both an increased incidence and accelerated onset of insulin- ... Cited by 50 - Related articles - All 4 versions
Z Ling, M Van de Casteele, DL Eizirik, DG Pipeleers - Diabetes, 2000 - Am Diabetes Assoc Previous work has shown that interleukin-1 ( I L-1 ) alters protein expression in -cells. This alteration
is associated with cell death in isolated rat islets but not in isolated rat -cells. We examined whether
IL-1 pr e- treatment of isolated -cells influences their sensitiv- ity to toxic agents. After a ... Cited by 19 - Related articles
