B Tyrberg, J Ustinov, T Otonkoski, A … - Diabetes, 2001 - Am Diabetes Assoc Neogenesis is crucial for the maintenance of β-cell mass in the human pancreas
and possibly for the outcome of clinical islet transplantation. To date, no
studies have reported a stimulation of human β-cell neogenesis in vivo. ... Cited by 35 - Related articles - BL Direct - All 7 versions
I Organ - Diabetes, 2001 - Am Diabetes Assoc Neogenesis is crucial for the maintenance of -cell mass in the human pancreas
and possibly for the out- come of clinical islet transplantation. To date, no
stud- ies have reported a stimulation of human -cell neoge- nesis in vivo. ... Related articles - All 2 versions
I Rooman, L Bouwens - Diabetologia, 2004 - Springer Aims/hypothesis. Increasing beta-cell mass and/or function could restore glucose
homeostasis in diabetes mellitus. Hitherto, trophic factors for beta-cell regen-
eration after toxic events have been difficult to identi- fy. We evaluated ... Cited by 63 - Related articles - BL Direct - All 4 versions
[CITATION] Insulin secretion in type-2 diabetes mellitus
KS Polonsky - International journal of obesity and related metabolic …, 2000 - ncbi.nlm.nih.gov Insulin resistance and compensatory hyperinsulinemia are commonly present in
obesity. The biochemical mechanisms responsible for the maintenance of basal
hypersecretion of insulin are reviewed in this article. Under basal, ... Cited by 32 - Related articles - BL Direct - All 2 versions
CF Howard, A Van Bueren - Diabetes, 1986 - Am Diabetes Assoc The islets of Langerhans in sections from the pancreas tail of Macaca nigra were
stained by antiserum to insulin, glucagon, or somatostatin. The area of stained
cells per total area of the islets was determined by a computerized ... Cited by 19 - Related articles - All 5 versions
- ►diabetesjournals.org [PDF] GM Beattie, P Itkin-Ansari, V Cirulli, G … - Diabetes, 1999 - Am Diabetes Assoc Ex vivo expansion of human ß-cells is an important step toward the development
of cell-based insulin delivery systems in type 1 diabetes. Here, we report that
human pancreatic endocrine cells can be expanded through 15 cell doublings ... Cited by 118 - Related articles - BL Direct - All 4 versions
I Rooman, J Lardon, L Bouwens - Diabetes, 2002 - Am Diabetes Assoc It is still unclear which factors regulate pancreatic regeneration and β-cell
neogenesis and which precursor cells are involved. We evaluated the role of
intravenously infused gastrin in regenerating pancreas of duct-ligated ... Cited by 103 - Related articles - BL Direct - All 4 versions
- ►endojournals.org WL Suarez-Pinzon, JRT Lakey, SJ Brand, A … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Pancreatic islet transplantation is a viable treatment for type 1 diabetes, but
is limited by human donor tissue availability. The combination of epidermal
growth factor (EGF) and gastrin induces islet ß-cell neogenesis from ... Cited by 68 - Related articles - All 5 versions
I Rooman, J Lardon, D Flamez, F Schuit, L … - Gastroenterology, 2001 - Elsevier Ductular metaplastic cells are observed during pancreas injury. Growth control
by gastrin and expression of gastrin/cholecystokinin (CCK) B receptors were
evaluated in these cells. Acinoductal transdifferentiation was induced in ... Cited by 55 - Related articles - BL Direct - All 10 versions
