- ►diabetesjournals.org I Briaud, JS Harmon, CL Kelpe, VBG Segu, V … - Diabetes, 2001 - Am Diabetes Assoc Prolonged exposure of isolated islets to supraphysiologic concentrations of
palmitate decreases insulin gene expression in the presence of elevated glucose
levels. This study was designed to determine whether or not this phenomenon ... Cited by 139 - Related articles - BL Direct - All 6 versions
S Jacqueminet, I Briaud, C Rouault, G Reach, … - Metabolism, 2000 - Elsevier Long-term exposure of pancreatic β cells to elevated levels of fatty acids
(FAs) impairs glucose-induced insulin secretion.However, the effects of FAs on
insulin gene expression are controversial. We hypothesized that FAs ... Cited by 68 - Related articles - BL Direct - All 4 versions
- ►endojournals.org B Ritz-Laser, P Meda, I Constant, N Klages, A … - Endocrinology, 1999 - Endocrine Soc Prolonged exposure to elevated FFA levels has been shown to induce peripheral
insulin resistance and to alter the ß-cell secretory response to glucose. To
investigate the effects of FFAs on preproinsulin gene expression, we ... Cited by 62 - Related articles - BL Direct - All 5 versions
- ►jbc.org S Gremlich, C Bonny, G Waeber, B Thorens - Journal of Biological Chemistry, 1997 - ASBMB IDX-1 (islet/duodenum homeobox-1) is a transcription factor expressed in the
duodenum and pancreatic beta and delta cells. It is required for embryonic
development of the pancreas and transactivates the Glut2, glucokinase, ... Cited by 168 - Related articles - BL Direct - All 5 versions
CL Kelpe, LM Johnson, V Poitout - Endocrinology, 2002 - Endocrine Soc The mechanisms by which prolonged exposure to elevated levels of fatty acids
(FA) adversely affects pancreatic ß-cell function remain unclear. Studies in
the Zucker diabetic fatty rat have suggested that excessive accumulation of ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] E Roche, S Farfari, LA Witters, F … - Diabetes, 1998 - Am Diabetes Assoc Chronic exposure of pancreatic -cells to high glucose has pleiotropic action on
-cell function. In particular, it induces key glycolytic genes, promotes
glycogen deposition, and causes -cell proliferation and altered insulin ... Cited by 91 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Cnop, JC Hannaert, A Hoorens, DL Eizirik, … - Diabetes, 2001 - Am Diabetes Assoc Studies in Zucker diabetic fatty rats have led to the concept that chronically
elevated free fatty acid (FFA) levels can cause apoptosis of triglyceride-laden
pancreatic β-cells as a result of the formation of ceramides, which induce ... Cited by 217 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org I Briaud, CL Kelpe, LM Johnson, POT Tran, V … - Diabetes, 2002 - Am Diabetes Assoc Chronic elevations in plasma levels of fatty acids (FAs) adversely affect
pancreatic β-cell function in type 2 diabetes. In vitro, we have previously
shown that deleterious effects of prolonged exposure of isolated islets to ... Cited by 50 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org JS Harmon, CE Gleason, Y Tanaka, V Poitout … - Diabetes, 2001 - Am Diabetes Assoc Type 2 diabetes is caused by a combination of β-cell dysfunction and insulin
resistance. Over time, hyperglycemia worsens, a phenomenon that has been
attributed to deleterious effects of chronic hyperglycemia (glucotoxicity) ... Cited by 76 - Related articles - BL Direct - All 4 versions
CL Kelpe, PC Moore, SD Parazzoli, B … - Journal of Biological Chemistry, 2003 - ASBMB Chronic exposure to elevated levels of fatty acids impairs pancreatic beta cell
function, a phenomenon thought to contribute to the progressive deterioration of
insulin secretion in type 2 diabetes. We have previously demonstrated that ... Cited by 66 - Related articles - BL Direct - All 6 versions
