SLF Chan, M Mourtada, NG Morgan - Diabetes, 2001 - Am Diabetes Assoc Efaroxan, like several other imidazoline reagents, elicits a glucose-dependent increase in insulin
secretion from pancreatic β-cells. This response has been attributed to efaroxan-mediated blockade
of K ATP channels, with the subsequent gating of voltage-sensitive calcium channels. ... Cited by 31 - Related articles - BL Direct - All 7 versions
AM Efanov, SV Zaitsev, HJ Mest, A Raap, IB Appelskog … - Diabetes, 2001 - Am Diabetes Assoc The insulinotropic activity of the novel imidazoline compound BL11282 was investigated. Intravenous
administration of BL11282 (0.3 mg · kg –1 · min –1 ) to anesthetized rats did not change blood
glucose and insulin levels under basal conditions, but produced a higher increase in ... Cited by 41 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org S Efendic, AM Efanov, PO Berggren, SV Zaitsev - Diabetes, 2002 - Am Diabetes Assoc The imidazoline RX871024 increased basal- and glucose-stimulated insulin release in vitro
and in vivo. The compound inhibited activity of ATP-sensitive K + channels as well as
voltage-gated K + channels, which led to membrane depolarization, an increase in the ... Cited by 26 - Related articles - BL Direct - All 4 versions
LK Monks, KE Cosgrove, MJ Dunne, CA Ramsden, N G … - FEBS letters, 1999 - Elsevier We have employed an amino derivative of the imidazoline ligand, efaroxan, to isolate imidazoline
binding proteins from solubilised extracts of rat brain, by affinity chromatography. A number of
proteins were specifically retained on the affinity column and one of these was ... Cited by 19 - Related articles - All 6 versions
I Rustenbeck, C Herrmann, P Ratzka, A … - … Schmiedeberg's archives of …, 1997 - Springer Abstract To elucidate the β-cytotropic effect of imidazo- line compounds their inhibitory effect
on ATP-dependent K + channels (K ATP channels) in pancreatic B-cells was compared with
their binding to membranes from insulin- secreting HIT T15 cells. K ATP channels in ... Cited by 30 - Related articles - BL Direct - All 3 versions
I Rustenbeck, L Leupolt, R Kowalewski, A … - … archives of pharmacology, 1999 - Springer Abstract Imidazolines are regarded as a pharmacological group of insulin secretagogues with
one uniform mecha- nism of action, namely closure of ATP-dependent K ... Key words Imidazoline
compounds · Insulin secretion · Cytosolic calcium concentration · Plasma membrane ... Cited by 15 - Related articles - BL Direct - All 4 versions
SLF Chan, AL Pallett, J Clews, CA Ramsden, JC … - European journal of …, 1998 - Elsevier The insulin secretagogue activity of certain imidazoline compounds is mediated by a binding
site associated with ATP-sensitive K + (K ATP ) channels in the pancreatic β-cell. We describe
the effects of a series of structural modifications to efaroxan on its activity at this site. ... Cited by 22 - Related articles - All 4 versions
G Mayer, PV Taberner - European Journal of Pharmacology, 2002 - Elsevier The putative imidazoline I 3 receptor antagonist 2-(2-ethyl-2,3-dihydrobenzo[b]furan-2-yl)-1H
-imidazole (KU14R) has been shown to block the effects of the atypical I 3 agonist efaroxan at
the level of the ATP-sensitive K + (K ATP ) channel in isolated pancreatic islet β cells, but ... Cited by 9 - Related articles - All 3 versions
AM Efanov, M Høy, R Bränström, SV Zaitsev, MA … - … and Biophysical Research …, 2001 - Elsevier Effects of the imidazoline compound RX871024 on cytosolic free Ca 2+ concentration ([Ca
2+ ] i ) and insulin secretion in pancreatic β-cells from SUR1 deficient mice have been
studied. In β-cells from wild-type mice RX871024 increased [Ca 2+ ] i by blocking ATP- ... Cited by 14 - Related articles - BL Direct - All 5 versions
C Bleck, A Wienbergen, I Rustenbeck - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Imidazolines are a class of investigational antidiabetic drugs. It is still
unclear whether the imidazoline ring is decisive for insulinotropic char- acteristics. Materials
and methods: We studied the imidazoline efaroxan and its imidazole analogue, KU14R, ... Cited by 9 - Related articles - BL Direct - All 4 versions
