JA Cases, I Gabriely, XH Ma, XM Yang, T Michaeli, N … - Diabetes, 2001 - Am Diabetes Assoc The demonstration of leptin receptors on the pancreatic β-cells suggests the possibility of direct
actions of leptin on insulin secretion. In vitro studies on islets or perfused pancreas and β-cell
lines produced inconsistent results. We performed an in vivo study to distinctly examine ... Cited by 71 - Related articles - BL Direct - All 5 versions
- ►physiology.org BO Ahren, PJ Havel - American Journal of Physiology- Regulatory …, 1999 - Am Physiological Soc The effect of leptin on insulin secretion is controversial due to conflicting results in the
literature. In the present study, we incubated insulin-producing rat insulinoma INS-1 cells for
60 min and examined the effects of recombinant murine leptin (20 nmol/l). We found that ... Cited by 39 - Related articles - BL Direct - All 4 versions
N Chinookoswong, JL Wang, ZQ Shi… - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc Leptin has been shown to improve insulin sensitivity and glucose metabolism in normoinsulinemic
healthy or obese rodents. It has not been determined whether leptin may act independently of
insulin in regulating energy metabolism in vivo. The present study was designed to ... Cited by 84 - Related articles - BL Direct - All 4 versions
M Ookuma, K Ookuma, DA York - Diabetes, 1998 - Am Diabetes Assoc Leptin is a hormone secreted by adipocytes as a peripheral metabolic signal for the central regulation
of energy homeostasis or the reproductive system. Recent studies demonstrated that leptin receptor
mRNA is expressed in pancreatic islets of rodents and that leptin at relatively high doses ... Cited by 81 - Related articles - BL Direct - All 5 versions
- ►physiology.org TJ Kieffer, JF Habener - American Journal of Physiology- …, 2000 - Am Physiological Soc The prevalence of obesity and related diabetes mellitus is increasing worldwide. Here we review
evidence for the existence of an adipoinsular axis, a dual hormonal feedback loop involving
the hormones insulin and leptin produced by pancreatic -cells and adipose tissue, ... Cited by 223 - Related articles - BL Direct - All 3 versions
- ►nih.gov [PDF] NG Chen, AG Swick, DR Romsos - Journal of Clinical …, 1997 - pubmedcentral.nih.gov Hypersecretion of insulin from the pancreas is among the earliest detectable metabolic alterations
in some genetically obese animals including the ob/ob mouse and in some obe- sity-prone
humans. Since the primary cause of obesity in the ob/ob mouse is a lack of leptin due to a ... Cited by 55 - Related articles - BL Direct - All 6 versions
Y Minokoshi, B Kahn - Biochemical Society Transactions, 2003 - bst.portlandpress.com Leptin regulates energy homoeostasis through central and peripheral mechanisms. Initial steps
in leptin action include signalling through a cytokine-like receptor which activates the JAK/STAT
pathway. We investigated whether the metabolic effects of leptin in muscle could be ... Cited by 62 - Related articles - Cached - BL Direct - All 9 versions
J Seufert - Diabetes, 2004 - Am Diabetes Assoc The hormone leptin is secreted from white adipocytes, and serum levels of leptin correlate with
adipose tissue mass. Leptin was first described to act on the satiety center in the hypothalamus
through specific receptors (leptin receptor [ObR]) to restrict food intake and enhance ... Cited by 97 - Related articles - BL Direct - All 5 versions
- ►jbc.org LS Liu, GB Karkanias, JC Morales, M Hawkins, N … - Journal of Biological …, 1998 - ASBMB Acute intravenous infusions of leptin markedly alter hepatic glucose fluxes (Rossetti, L.,
Massillon, D., Barzilai, N., Vuguin, P., Chen, W., Hawkins, M., Wu, J., and Wang, J. (1997) J.
Biol. Chem. 272, 27758-22763). Here we examine whether intracerebroventricular (ICV) ... Cited by 136 - Related articles - BL Direct - All 6 versions
