- ►diabetesjournals.org G Xu, G Kwon, WS Cruz, CA Marshall, ML … - Diabetes, 2001 - Am Diabetes Assoc Recent findings have demonstrated that the branched-chain amino acid leucine can
activate the translational regulators, phosphorylated heat- and acid-stable
protein regulated by insulin (PHAS-I) and p70 S6 kinase (p70 s6k ), in an ... Cited by 85 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org ML McDaniel, CA Marshall, KL Pappan, G … - Diabetes, 2002 - Am Diabetes Assoc Mammalian target of rapamycin (mTOR) is a serine and threonine protein kinase
that regulates numerous cellular functions, in particular, the initiation of
protein translation. mTOR-mediated phosphorylation of both the ... Cited by 43 - Related articles - BL Direct - All 4 versions
CJ Lynch, HL Fox, TC Vary, LS Jefferson, SR … - Journal of Cellular Biochemistry, 2000 - interscience.wiley.com In adipocytes, amino acids stimulate the target of rapamycin (TOR) signaling
pathway leading to phosphorylation of the translational repressor, eIF-4E
binding protein-I (4E-BP1), and ribosomal protein S6. L-leucine is the ... Cited by 76 - Related articles - BL Direct - All 3 versions
- ►nutrition.org CJ Lynch - Journal of Nutrition, 2001 - Am Soc Nutrition In this study an overview is presented of the mTOR signaling pathway and its
regulation by amino acids, particularly L-leucine. Our laboratory is studying
amino acid regulation of mTOR in adipocytes. Potential roles for mTOR in ... Cited by 46 - Related articles - All 6 versions
G Xu, G Kwon, CA Marshall, TA Lin, JC … - Journal of Biological Chemistry, 1998 - ASBMB Amino acids have been identified as important signaling molecules involved in
pancreatic β-cell proliferation, although the cellular mechanism responsible
for this effect is not well defined. We previously reported that amino ... Cited by 172 - Related articles - BL Direct - All 4 versions
K Shigemitsu, Y Tsujishita, H Miyake, S … - FEBS letters, 1999 - Elsevier The addition of leucine induced activation of p70 S6k in amino acid-depleted
H4IIE cells. Whereas the activation of p70 S6k by leucine was transient, the
complete amino acid stimulated p70 S6k more persistently. The effect of ... Cited by 62 - Related articles - All 6 versions
- ►jbc.org Y Iiboshi, PJ Papst, H Kawasome, H Hosoi, … - Journal of Biological Chemistry, 1999 - ASBMB In human T-lymphoblastoid cells, downstream signaling events of mammalian target
of rapamycin (mTOR), including the activity of p70 s6k and phosphorylation of
eukaryotic initiation factor 4E-binding protein 1, were dependent on amino ... Cited by 149 - Related articles - All 4 versions
- ►diabetesjournals.org LJC van Loon, M Kruijshoop, PPCA … - Diabetes Care, 2003 - Am Diabetes Assoc OBJECTIVE—Insulin secretion in response to carbohydrate intake is blunted in
type 2 diabetic patients. However, it is not clear whether the insulin response
to other stimuli, such as amino acids, is also diminished. Recently, we ... Cited by 39 - Related articles - BL Direct - All 6 versions
- ►jbc.org G Xu, CA Marshall, TA Lin, G Kwon, RB … - Journal of Biological Chemistry, 1998 - ASBMB Although glucose regulates the biosynthesis of a variety of beta cell proteins
at the level of translation, the mechanism responsible for this effect is
unknown. We demonstrate that incubation of pancreatic islets with elevated ... Cited by 67 - Related articles - BL Direct - All 5 versions
JC Floyd, SS Fajans, S Pek, CA Thiffault, RF … - Diabetes, 1970 - Am Diabetes Assoc Diabetes Skip to main page content. Home; Current Issue; Archive; Contact; Subscribe;
Alerts; Help. rss feed. Search GO. Advanced Search ». User Name Password Sign ... Cited by 28 - Related articles - All 3 versions
