TJ Kowalski, SM Liu, RL Leibel, SC Chua - Diabetes, 2001 - Am Diabetes Assoc Mice homozygous for the Lepr db3J (db 3J ) mutation are null for all known
isoforms of the leptin receptor (LEPR). These animals are obese, hyperphagic,
cold intolerant, insulin resistant, and infertile. Mice homozygous for the ... Cited by 52 - Related articles - BL Direct - All 5 versions
JE McMinn, SM Liu, I Dragatsis, P Dietrich, T … - Mammalian Genome, 2004 - Springer 1 Department of Pediatrics, Division of Molecular Genetics, Columbia University
College of Physicians and Surgeons, New York New York 10032, USA 2 Department of
Physiology, University of Tennessee, Memphis, Tennessee 38163, USA 3 ... Cited by 16 - Related articles - BL Direct - All 5 versions
SC Chua - Behavior genetics, 1997 - Springer The study of rodent monogenic models of obesity has yielded significant insights
into the pathogenesis of obesity. Multiple independent mutations in several
genes can produce obesity. As these genes act in different regulatory ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►nih.gov P Cohen, C Zhao, X Cai, JM Montez, SC … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig Animals with mutations in the leptin receptor (ObR) exhibit an obese phenotype
that is indistinguishable from that of leptin deficient ob/ob mice. ObR is
expressed in many tissues, including brain, and the relative importance of ... Cited by 214 - Related articles - BL Direct - All 9 versions
- ►physiology.org SC Chua Jr, SM Liu, Q Li, A Sun, WF DeNino, … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc We have generated mice that are homozygous for a leptin receptor transgene that
is expressed exclusively in neurons (NSE-LEPR-B). We had previously shown that
this transgene in the hemizygous state is effective in ameliorating almost ... Cited by 11 - Related articles - BL Direct - All 5 versions
- ►physiology.org JE McMinn, SM Liu, H Liu, I Dragatsis, P … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc Leptin signaling in the brain regulates energy intake and expenditure. To test
the degree of functional neuronal leptin signaling required for the maintenance
of body composition, fertility, and cold tolerance, transgenic mice ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] C de Luca, TJ Kowalski, Y Zhang, JK … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig 1 Department of Medicine, Division of Preventative Medicine, Columbia
University, New York, New York, USA. 2 Department of Cardiovascular
Branch/Endocrinology Biological Research, Central Nervous ... Cited by 60 - Related articles - BL Direct - All 11 versions
SC Chua, IK Koutras, L Han, SM Liu, J Kay, … - Genomics, 1997 - Elsevier The fine structure of the murine leptin receptor gene (Lepr) is described.
Duplicated ligand binding domains (conserved among cytokine receptors) are found
in eight exons (coding exons 3 to 6 and 8 to 11). Thus, it is possible that ... Cited by 73 - Related articles - BL Direct - All 5 versions
P Hekerman, J Zeidler, S Bamberg-Lemper, H … - FEBS Journal, 2005 - interscience.wiley.com The leptin receptor (LEPR) is a class I cytokine receptor signalling via both
the janus kinase/signal transducer and activator of transcription (JAK/STAT) and
the MAP kinase pathways. In addition, leptin has been shown previously to ... Cited by 38 - Related articles - All 2 versions
S Chua, S Mei Liu, Q Li, L Yang, V … - Diabetologia, 2002 - Springer Aims. Our goal was to identify genetic variants that determine the response to
insulin resistance and hy- perglycaemia. This report documents the diabetes syn-
drome of two new congenic strains of mice generated by the transfer of the ... Cited by 27 - Related articles - BL Direct - All 4 versions
