H Zulewski, EJ Abraham, MJ Gerlach, PB Daniel, W … - Diabetes, 2001 - Am Diabetes Assoc The endocrine cells of the rat pancreatic islets of Langerhans, including insulin-producing
β-cells, turn over every 40–50 days by processes of apoptosis and the proliferation and differentiation
of new islet cells (neogenesis) from progenitor epithelial cells located in the pancreatic ... Cited by 629 - Related articles - BL Direct - All 7 versions
S Bonner-Weir, M Taneja, GC Weir, K … - Proceedings of the …, 2000 - National Acad Sciences A major obstacle to successful islet transplantation for both type 1 and 2 diabetes is an inadequate
supply of insulin-producing tissue. This need for transplantable human islets has stimulated efforts
to expand existing pancreatic islets and/or grow new ones. To test the hypothesis that ... Cited by 744 - Related articles - BL Direct - All 10 versions
VK Ramiya, M Maraist, KE Arfors, DA Schatz, AB … - Nature medicine, 2000 - ntbiomol.unibe.ch Islets of Langerhans have a cellular organization ideal for rapid, yet finely controlled, responses
to changes in blood glu- cose levels1–6. During embryogenesis, islet development seems to
be initiated from stem cells associated with the pancreatic ductal epithelium that ... Cited by 614 - Related articles - View as HTML - BL Direct - All 5 versions
- ►colorado.edu [PDF] N Lumelsky, O Blondel, P Laeng, I Velasco, R Ravin, R … - Science, 2001 - sciencemag.org Although the source of embryonic stem (ES) cells presents ethical concerns, their use may lead
to many clinical benefits if differentiated cell types can be derived from them and used to assemble
functional organs. In pancreas, insulin is produced and secreted by specialized ... Cited by 1083 - Related articles - BL Direct - All 18 versions
- ►endojournals.org EJ Abraham, CA Leech, JC Lin, H Zulewski, JF … - Endocrinology, 2002 - Endocrine Soc Glucagon-like peptide-1 (GLP-1) is an intestinal incretin hormone, derived from the processing
of proglucagon, that exerts insulinotropic actions on insulin-producing pancreatic islet
ß-cells. Recently GLP-1 was shown to stimulate the growth and differentiation ... Cited by 238 - Related articles - BL Direct - All 4 versions
B Soria, E Roche, G Berna, T León-Quinto, … - DIABETES-NEW …, 2000 - Am Diabetes Assoc Embryonic stem (ES) cells display the ability to dif- ferentiate in vitro into a variety of cell
lineages. Using a cell-trapping system, we have obtained an insulin- secreting cell clone from
undifferentiated ES cells. The construction used allows the expression of a neomycin ... Cited by 697 - Related articles - BL Direct - All 4 versions
E Hunziker, M Stein - Biochemical and Biophysical Research …, 2000 - Elsevier The pancreatic islets of Langerhans produce several peptide hormones, predominantly the metabolically
active hormones insulin and glucagon, which are critical for maintaining normal fuel
homeostasis. Some evidence exists that pancreatic endocrine cells turn over at a slow ... Cited by 135 - Related articles - BL Direct - All 5 versions
- ►nih.gov L Yang, S Li, H Hatch, K Ahrens, JG … - Proceedings of the …, 2002 - National Acad Sciences Although organ-specific stem cells possess plasticity that permit differentiation along new
lineages, production of endocrine pancreas and insulin-secreting β cells from adult nonpancreatic
stem cells has not been demonstrated. We present evidence that highly purified adult rat ... Cited by 404 - Related articles - BL Direct - All 13 versions
L Selander, H Edlund - Mechanisms of development, 2002 - Elsevier Stem cell research and the prospect of stem cell based therapies depend critically on the identification
of specific markers that can be used for the identification and selection of stem and progenitor
cells. Nestin is expressed in neuronal progenitor cells and has also been suggested to ... Cited by 128 - Related articles - All 5 versions
- ►colorado.edu [PDF] J Rajagopal, WJ Anderson, S Kume, OI Martinez, DA … - Science, 2003 - sciencemag.org Despite antibody staining, we did not detect insulin 1 mRNA by reverse transcription-polymerase
chain reaction (RT-PCR) and insulin 2 mRNA detection was weak. Multiple primers used during
all five stages of the protocol (1) confirmed these results. RT-PCR controls detected ... Cited by 359 - Related articles - All 5 versions
