J Wang, J Xu, J Finnerty, M Furuta, DF Steiner, CB … - Diabetes, 2001 - Am Diabetes Assoc Impaired processing of pro-islet amyloid polypeptide (proIAPP), the precursor of the β-cell peptide
islet amyloid polypeptide (IAPP) (amylin), has been implicated in islet amyloid formation in type
2 diabetes. The prohormone convertase enzymes PC3 (also known as PC1) and PC2 are ... Cited by 43 - Related articles - BL Direct - All 4 versions
CE Higham, RL Hull, L Lawrie, KIJ … - European Journal of …, 2000 - interscience.wiley.com Islet amyloid polypeptide (IAPP), amylin, is the constituent peptide of pancreatic islet amyloid
deposits which form in islets of Type 2 diabetic subjects. Human IAPP is synthesized as a
67-residue propeptide in islet β-cells and colocalized with insulin in β-cell granules. The ... Cited by 29 - Related articles - BL Direct - All 4 versions
L Marzban, G Trigo-Gonzalez, X Zhu, CJ Rhodes, PA … - Diabetes, 2004 - Am Diabetes Assoc Islet amyloid polypeptide (IAPP) (amylin), the major component of islet amyloid, is produced
by cleavage at the COOH- and NH 2 -termini of its precursor, proIAPP, likely by the β-cell prohormone
convertases (PC) 1/3 and PC2. Mice lacking PC2 can process proIAPP at its COOH- but ... Cited by 29 - Related articles - BL Direct - All 5 versions
MK Badman, KIJ Shennan, JL Jermany, K Docherty, A … - FEBS letters, 1996 - Elsevier Islet amyloid polypeptide (IAPP), 'amylin', is the component peptide of islet amyloid formed in
Type 2 diabetes. IAPP is expressed in islet β-cells and is derived from a larger precursor,
proIAPP, by proteolysis. An in vitro translation/translocation system was used to ... Cited by 49 - Related articles - All 6 versions
X Hou, Z Ling, E Quartier, A Foriers, F Schuit, D … - Diabetologia, 1999 - Springer Islet amyloid polypeptide (IAPP) is a 37 amino acid peptide that is produced by pancreatic beta
cells fol- lowing synthesis of (pre)pro-IAPP and proteolytic cleavage at dibasic lys-arg residues
[1]. The peptide is the predominant component of the amyloid depos- its which are often ... Cited by 25 - Related articles - BL Direct - All 3 versions
P Westermark, U Engström, GT Westermark, … - Diabetes research and …, 1989 - ncbi.nlm.nih.gov Islet amyloid polypeptide (IAPP) is a 37-amino-acid putative hormone which is expressed by
islet B-cells and most probably is co-released with insulin. IAPP is synthesized as an
89-amino-acid prepropeptide in which IAPP is flanked by two short peptides. The two ... Cited by 37 - Related articles
K Park, CB Verchere - Journal of Biological Chemistry, 2001 - ASBMB Islet amyloid deposits are a characteristic pathologic lesion of the pancreas in type 2 diabetes
and are composed primarily of the islet beta cell peptide islet amyloid polypeptide (IAPP or
amylin) as well as the basement membrane heparan sulfate proteoglycan perlecan. ... Cited by 38 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] WC Soeller, J Janson, SE Hart, JC Parker, MD Carty, … - Diabetes, 1998 - Am Diabetes Assoc We have previously shown that hemizygous transgenic mice expressing human islet amyloid
polypeptide (hIAPP) in pancreatic -cells have no diabetic pheno- type, whereas in the homozygous
state, they developed severe, early-onset hyperglycemia associated with impaired insulin ... Cited by 94 - Related articles - BL Direct - All 6 versions
M Krampert, J Bernhagen, J Schmucker, A Horn, A … - Chemistry & Biology, 2000 - Elsevier Results: We present a method for efficient recombinant expression and purification of ProIAPP
and a processing site mutant, mutProIAPP, as thioredoxin (Trx) fusion proteins. Conformation
and amyloidogenicity of cleaved ProIAPP and mutProIAPP and the fusion proteins were ... Cited by 21 - Related articles - BL Direct - All 16 versions
GT Westermark, DF Steiner, S Gebre-Medhin, … - Upsala journal of …, 2000 - ncbi.nlm.nih.gov Islet amyloid is typically found in type 2 diabetes mellitus and is believed to participate in the
beta cell deterioration. The islet amyloid fibril consists of the 37-amino-acid islet amyloid polypeptide
(IAPP) but its pathogenesis is only partly understood. We developed several different ... Cited by 18 - Related articles - BL Direct - All 2 versions
