- ►diabetesjournals.org FC Jonkers, JC Henquin - Diabetes, 2001 - Am Diabetes Assoc The proportion of isolated single β-cells developing a metabolic, biosynthetic,
or secretory response increases with glucose concentration (recruitment). It is
unclear whether recruitment persists in situ when β-cells are coupled. We ... Cited by 39 - Related articles - BL Direct - All 7 versions
MA Ravier, JC Henquin - FEBS letters, 2002 - Elsevier Glucose-induced insulin secretion is pulsatile. We investigated how the
triggering pathway (rise in β-cell [Ca 2+ ] i ) and amplifying pathway (greater
Ca 2+ efficacy on exocytosis) influence this pulsatility. Repetitive [Ca 2+ ... Cited by 16 - Related articles - All 7 versions
M Ravier, J Sehlin, J Henquin - Diabetologia, 2002 - Springer Aims/hypothesis. In normal mouse islets, glucose in- duces synchronous
cytoplasmic [Ca 2+ ] i oscillations in beta cells and pulses of insulin
secretion. We investi- gated whether this fine regulation of islet function ... Cited by 22 - Related articles - BL Direct - All 3 versions
P Gilon, MA Ravier, JC Jonas, JC Henquin - Diabetes, 2002 - Am Diabetes Assoc The mechanisms driving the pulsatility of insulin secretion in vivo and in vitro
are still unclear. Because glucose metabolism and changes in cytosolic free Ca
2+ ([Ca 2+ ] c ) in β-cells play a key role in the control of insulin ... Cited by 50 - Related articles - BL Direct - All 5 versions
CM Antunes, AP Salgado, LM Rosario, RM … - DIABETES-NEW YORK-, 2000 - Am Diabetes Assoc Although isolated rat islets are widely used to study in vitro insulin secretion
and the underlying metabolic and ionic processes, knowledge on the properties of
glucose-induced electrical activity (GIEA), a key step in glucose-response ... Cited by 44 - Related articles - BL Direct - All 5 versions
JC Jonas, P Gilon, JC Henquin - Diabetes, 1998 - Am Diabetes Assoc An increase in cytoplasmic Ca 2 + in -cells is a key step in glucose-induced
insulin secretion. However, whether changes in cytoplasmic free Ca 2+ ([Ca 2+ ]
i ) directly regu- late secretion remains disputed. This question was ... Cited by 63 - Related articles - BL Direct - All 4 versions
PE Squires, AC Hauge-Evans, SJ Persaud, … - Cell Calcium, 2000 - Elsevier The secretory response of the intact islet is greater than the response of
individual β-cells in isolation, and functional coupling between cells is
critical in insulin release. The changes in intracellular Ca 2+ ([Ca 2+ ] i ... Cited by 20 - Related articles - BL Direct - All 3 versions
MJ Garcia-Barrado, MA Ravier, JF Rolland, P … - Endocrinology, 2001 - Endocrine Soc Proteins with a short half-life are potential sites of pancreatic ß cell
dysfunction under pathophysiological conditions. In this study, mouse islets
were used to establish which step in the regulation of insulin secretion is ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►nih.gov FC Jonkers, JC Jonas, P Gilon, JC Henquin - The Journal of Physiology, 1999 - Physiological Soc In contrast, practically all clusters (2–50 cells) responded to glucose, and
no inert cells were identified within the clusters. As compared to single cells,
mean [Ca 2+ ] i was more elevated, [Ca 2+ ] i oscillations were more ... Cited by 76 - Related articles - BL Direct - All 9 versions
