A Hoorens, G Stangé, D Pavlovic, D Pipeleers - Diabetes, 2001 - Am Diabetes Assoc Interleukin (IL)-1β is known to cause β-cell death in isolated rat islets.
This effect has been attributed to induction of nitric oxide (NO) synthase in
β-cells and subsequent generation of toxic NO levels; it was not observed, ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] D Liu, D Pavlovic, MC Chen, M Flodström, S … - Diabetes, 2000 - Am Diabetes Assoc Prolonged exposure of rodent -cells to combinations of cytokines induces the
inducible form of nitric oxide synthase (iNOS) expression and Fas expression,
nitric oxide (NO) production, and cell death. It also induces the ... Cited by 165 - Related articles - BL Direct - All 5 versions
- ►endojournals.org CA Delaney, D Pavlovic, A Hoorens, DG … - Endocrinology, 1997 - Endocrine Soc We have previously observed that a 6-day exposure of human pancreatic islets to
a combination of cytokines (interleukin-1ß 50 U/ml + tumour necrosis factor-
1000 U/ml + interferon- 1000 U/ml) severely impairs ß-cell functions. In ... Cited by 257 - Related articles - BL Direct - All 3 versions
AK Cardozo, H Heimberg, Y Heremans, R Leeman … - Journal of Biological Chemistry, 2001 - ASBMB Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic
-cells. Cytokines, such as interleukin-1 and interferon- , are putative
mediators of immune-induced -cell death and, under in vitro conditions, ... Cited by 158 - Related articles - BL Direct - All 4 versions
- ►endojournals.org J Saldeen - Endocrinology, 2000 - Endocrine Soc The presence of activated macrophages within pancreatic islets in
insulin-dependent diabetes mellitus suggests an involvement of ß-cell death by
necrosis. The aim of this study was to investigate the frequencies and ... Cited by 93 - Related articles - BL Direct - All 5 versions
CA Gysemans, D Pavlovic, R Bouillon, DL … - Diabetologia, 2001 - Springer The ability of pancreatic islets to endure assaults of the immune system could
be relevant in the develop- ment of Type I (insulin-dependent) diabetes
mellitus. We and other investigators have suggested that inter- Cited by 17 - Related articles - BL Direct - All 4 versions
D Pavlovic, MC Chen, L Bouwens, DL Eizirik, … - DIABETES-NEW YORK-SUPPLEMENT, 1999 - Am Diabetes Assoc In type 1 diabetes, autoimmune destruction of pancre- atic -cells has been
attributed to cytokines released from infiltrating immunocytes. Exposure of
isolated islets to cytokines leads to nitric oxide (NO) produc- tion, which ... Cited by 56 - Related articles - BL Direct - All 4 versions
MS Baker, X Chen, XC Cao, DB Kaufman - Journal of Surgical Research, 2001 - Elsevier Background. Islet graft injury by cytokines released from inflammatory cells
(macrophages) that infiltrate the transplant site is an important mechanism of
early islet transplant dysfunction. This detrimental “cytokine effect” ... Cited by 43 - Related articles - BL Direct - All 12 versions
- ►diabetesjournals.org [PDF] Z Ling, M Van de Casteele, DL Eizirik, DG … - Diabetes, 2000 - Am Diabetes Assoc Previous work has shown that interleukin-1 ( I L-1 ) alters protein expression
in -cells. This alteration is associated with cell death in isolated rat islets
but not in isolated rat -cells. We examined whether IL-1 pr e- treatment of ... Cited by 48 - Related articles - BL Direct - All 3 versions
N Giannoukakis, WA Rudert, M Trucco, PD … - Journal of Biological Chemistry, 2000 - ASBMB Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that inhibits β cell
function and promotes Fas-triggered apoptosis. IL-1β is thought to act early in
the initiation of the autoimmune destruction of pancreatic β cells in type ... Cited by 127 - Related articles - BL Direct - All 4 versions
