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Insulin Resistance With Enhanced Insulin Signaling in High-Salt Diet–Fed Rats

- diabetesjournals.org
T Ogihara, T Asano, K Ando, Y Chiba, N Sekine, H … - Diabetes, 2001 - Am Diabetes Assoc
Previous clinical studies showed an apparent correlation between hypertension and insulin
resistance, and patients with diabetes are known to have increased blood pressure responsiveness
to salt loading. To investigate the effect of high salt intake on insulin sensitivity and the ...
Cited by 68 - Related articles - BL Direct - All 5 versions

High-salt diet enhances insulin signaling and induces insulin resistance in Dahl …

- ahajournals.org
T Ogihara, T Asano, K Ando, H Sakoda, M Anai, N … - Hypertension, 2002 - Am Heart Assoc
A high-salt diet, which is known to contribute to the pathogenesis of hypertension, is also reportedly
associated with insulin resistance. We investigated the effects of a high-salt diet on insulin sensitivity
and insulin signaling in salt-sensitive (Dahl-S) and salt resistant (Dahl-R) strains of the ...
Cited by 60 - Related articles - BL Direct - All 6 versions

Effect of sodium intake on insulin sensitivity


DS Donovan, CG Solomon, EW Seely, GH … - American Journal of …, 1993 - Am Physiological Soc
Seely, Gordon H. Williams, and Donald C. Simonson. Effect of sodium intake on insulin
sensitivity. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E730-E734, 1993.--o examine the effects
of sodium intake on insulin sensitivity, we performed euglycemic insulin clamp studies (40 ...
Cited by 62 - Related articles - BL Direct - All 4 versions

Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver …

- diabetesjournals.org [PDF] 
M Anai, M Funaki, T Ogihara, A Kanda, Y Onishi, H … - Diabetes, 1999 - Am Diabetes Assoc
Insulin receptor substrate (IRS)-1 and IRS-2, which mediate phosphatidylinositol (PI) 3-kinase
activation, play essential roles in insulin-induced translocation of GLUT4 and in glycogen
synthesis. In this study, we investigated the process of PI 3-kinase activation via binding ...
Cited by 67 - Related articles - BL Direct - All 5 versions

Contribution of salt intake to insulin resistance associated with hypertension


T Ogihara, T Asano, T Fujita - Life sciences, 2003 - Elsevier
It is well-known that excessive salt intake induces elevation of blood pressure and that hypertension
often coexists with insulin resistance. However, the contribution made by salt intake to the development
of insulin resistance remains unclear. In this minireview, the insulin resistance seen in ...
Cited by 22 - Related articles - All 5 versions

The effect of dietary salt on insulin sensitivity


D Fliser, P Fode, U Arnold, M Nowicki, B … - European journal of …, 1995 - interscience.wiley.com
Abstract. Acute reduction of salt intake causes an increase in serum lipid and insulin levels in
healthy volunteers and patients with essential hypertension, suggesting induction of insulin resistance
by salt restriction. Direct measurements of insulin sensitivity using the euglycaemic clamp ...
Cited by 23 - Related articles - BL Direct - All 4 versions

Salt Sensitivity Is Associated With Insulin Resistance in Essential Hypertension&ast


N Fuenmayor, E Moreira, LX Cubeddu - 1998 - nature.com
The relationship between salt sensitivity and insulin resistance was investigated in
nondiabetic, nonobese (body mass index 28) untreated patients with uncomplicated,
mild-to-moderate essential hypertension. Alterations in insulin-mediated glucose disposal ...
Cited by 65 - Related articles - All 5 versions

Angiotensin II-induced insulin resistance is associated with enhanced insulin …

- ahajournals.org
T Ogihara, T Asano, K Ando, Y Chiba, H Sakoda, M … - Hypertension, 2002 - Am Heart Assoc
Angiotensin II (AII) is involved in the pathogenesis of both hypertension and insulin
resistance, though few studies have examined the relationship between the two. We therefore
investigated the effects of chronic AII infusion on blood pressure and insulin sensitivity in ...
Cited by 141 - Related articles - BL Direct - All 6 versions

High-or low-salt diet from weaning to adulthood: effect on insulin sensitivity in …

- ahajournals.org
PO Prada, MM Okamoto, LNS Furukawa, UF Machado, … - Hypertension, 2000 - Am Heart Assoc
Abstract—Because of conflicting results in the literature, further studies are needed to confirm
an association between the degree of salt consumption and insulin sensitivity. The aim of this
study was to measure insulin sensitivity in rats fed from weaning to adulthood with a low ( ...
Cited by 37 - Related articles - BL Direct - All 7 versions

Insulin stimulated glycogen synthesis in isolated rat hepatocytes: effect of protein …


J Carlsen, K Christiansen, J Vinten - Cellular signalling, 1997 - Elsevier
Glycogen synthesis was studied in rat hepatocytes isolated by EDTA perfusion. Insulin induced
a one and a half to twofold increase in glucose incorporation into glycogen. Insulin stimulated
glycogen synthesis was inhibited by the phosphatidylinositol 3-kinase inhibitors ...
Cited by 24 - Related articles - BL Direct - All 5 versions


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