A Parker, J Meyer, S Lewitzky, JS Rennich, G Chan, JD … - Diabetes, 2001 - Am Diabetes Assoc Genome-wide nonparametric linkage analysis of 480 sib-pairs affected with type 2 diabetes revealed
linkage to a previously unreported susceptibility locus on chromosome 18p11. This result improved
with stringent subphenotyping using age- and sex-adjusted BMI, ultimately reaching a ... Cited by 89 - Related articles - BL Direct - All 6 versions
- ►nih.gov CM Lindgren, MM Mahtani, E Widen, MI McCarthy, … - The American Journal of …, 2002 - Elsevier Type 2 diabetes mellitus is a heterogeneous inherited disorder characterized by chronic hyperglycemia
resulting from pancreatic β-cell dysfunction and insulin resistance. Although the pathogenic mechanisms
are not fully understood, manifestation of the disease most likely requires interaction ... Cited by 117 - Related articles - BL Direct - All 9 versions
- ►nih.gov F Busfield, DL Duffy, JB Kesting, SM Walker, PK … - The American Journal of …, 2002 - Elsevier The prevalence of type 2 diabetes among Australian residents is 7.5%; however, prevalence
rates up to six times higher have been reported for indigenous Australian communities. Epidemiological
evidence implicates genetic factors in the susceptibility of indigenous Australians to type ... Cited by 59 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] MG Ehm, MC Karnoub, H Sakul, K Gottschalk, DC … - The American Journal of …, 2000 - Elsevier Type 2 diabetes is a serious, genetically influenced disease for which no fully effective treatments
are available. Identification of biochemical or regulatory pathways involved in the disease syndrome
could lead to innovative therapeutic interventions. One way to identify such pathways is ... Cited by 115 - Related articles - BL Direct - All 5 versions
TH Luo, Y Zhao, G Li, WT Yuan, JJ Zhao, JL Chen, W … - Diabetologia, 2001 - Springer Type II (non-insulin-dependent) diabetes mellitus is a major health problem in many developed
countries. In developing countries, like China, the prevalence of Type II diabetes has statistically
significantly in- creased in recent years, especially along with eco- nomic growth. In ... Cited by 116 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org MA Permutt, JC Wasson, BK Suarez, J Lin, J Thomas, J … - Diabetes, 2001 - Am Diabetes Assoc A total of 896 individuals of Ashkenazi Jewish descent were ascertained in Israel from 267 multiplex
families, including 472 sib-pairs affected with type 2 diabetes. A genome-wide scan with average
marker spacing of 9.5 cM revealed five regions on four chromosomes (4q, 8q, 14q, and ... Cited by 123 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] A Bektas, ME Suprenant, LT Wogan, N Plengvidhya, … - Diabetes, 1999 - Am Diabetes Assoc To replicate the recent finding of a type 2 diabetes locus (NIDDM 2) on 12q, families segregating
early- onset autosomal-dominant type 2 diabetes were screened for linkage. Included were 26
Caucasian and 6 non-Caucasian pedigrees with an average age at dia- betes diagnosis ... Cited by 41 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] JT Shaw, PK Lovelock, JB Kesting, J Cardinal, D Duffy, … - Diabetes, 1998 - Am Diabetes Assoc NIDDM has a substantial genetic component, but the nature of the genetic susceptibility is largely
unknown. Maturity-onset diabetes of the young (MODY) is a genetically heterogeneous monogenic
form of NIDDM characterized by an early age of onset and autosomal dominant ... Cited by 66 - Related articles - BL Direct - All 4 versions
YS Aulchenko, N Vaessen, P Heutink, J Pullen, PJLM … - Diabetes, 2003 - Am Diabetes Assoc Multiple genes, interacting with the environment, contribute to the susceptibility to type 2
diabetes. We performed a genome-wide search to localize type 2 diabetes susceptibility genes
in a recently genetically isolated population in the Netherlands. We identified 79 nuclear ... Cited by 27 - Related articles - BL Direct - All 8 versions
- ►endojournals.org JHO Van Tilburg, LA Sandkuijl, E Strengman, H … - Journal of Clinical …, 2003 - Endocrine Soc A genome-wide scan was performed, using nonparametric linkage analyses, to find susceptibility
loci for type 2 diabetes mellitus in the Dutch population. We studied 178 families from The
Netherlands, who constituted 312 affected sibling pairs. The first stage of the genome ... Cited by 36 - Related articles - BL Direct - All 9 versions
