J Luan, PO Browne, AH Harding, DJ Halsall, SO'Rahilly … - Diabetes, 2001 - Am Diabetes Assoc The importance of the nuclear receptor peroxisome proliferator–activated receptor-γ
(PPARγ) in regulating insulin resistance and blood pressure has been demonstrated in families
with loss of function mutations. Gain of function mutations has been associated with ... Cited by 230 - Related articles - BL Direct - All 5 versions
J Robitaille, JP Despres, L Perusse, MC Vohl - Clinical genetics, 2003 - interscience.wiley.com The metabolic syndrome is a complex disorder characterized by an atherogenic dyslipidemia
resulting from the interaction between genetic and nutritional factors. The objective of this study
was to examine in a cohort of 720 adults participating in the Québec Family Study (QFS) ... Cited by 84 - Related articles - BL Direct - All 4 versions
VKK Chatterjee, NJ Wareham - DIABETES, 2001 - Am Diabetes Assoc The importance of the nuclear receptor peroxisome proliferator–activated receptor- (PPAR ) in
regulat- ing insulin resistance and blood pressure has been demonstrated in families with loss
of function muta- tions. Gain of function mutations has been associated with severe ... Related articles
- ►oxfordjournals.org A Memisoglu, FB Hu, SE Hankinson, JAE … - Human Molecular …, 2003 - Oxford Univ Press The peroxisome proliferator-activated receptor (PPAR ) is a critical regulator of
adipogenesis. PPAR +/- mice are resistant to high-fat diet-induced obesity and thus PPAR may
mediate physiological responses to dietary fat in other mammals. The aim of this study ... Cited by 90 - Related articles - All 6 versions
- ►endojournals.org R Valve, K Sivenius, R Miettinen, J Pihlajamaki, … - Journal of Clinical …, 1999 - Endocrine Soc Peroxisome proliferator-activated receptor- (PPAR ) is a nuclear receptor that regulates adipocyte
differentiation. Variations in the PPAR gene may affect the function of the PPAR and,
therefore, body adipocity. We investigated the frequencies of the Pro 12 Ala ... Cited by 180 - Related articles - BL Direct - All 10 versions
BJ Nicklas, EFC van Rossum, DM Berman, AS Ryan, … - Diabetes, 2001 - Am Diabetes Assoc This study determined the effects of the peroxisome proliferator–activated receptor (PPAR)-γ2
Pro12Ala variant on body composition and metabolism and the magnitude of weight regain in
70 postmenopausal women (BMI 25–40 kg/m 2 ) who completed 6 months of a ... Cited by 87 - Related articles - BL Direct - All 5 versions
BA Beamer, CJ Yen, RE Andersen, D Muller, … - DIABETES-NEW …, 1998 - Am Diabetes Assoc T he nuclear receptor, peroxisome proliferator- act i- vated receptor- ( P PA R - ), is an important
regula- tor of adipocyte differentiation and a modulator of intracellular insulin-signaling events
(1). PPA R - mRNA expression in both skeletal muscle and adipose tissue in vitro is ... Cited by 210 - Related articles - BL Direct - All 5 versions
PW Franks, J Luan, PO Browne, AH Harding, SO' … - Metabolism, 2004 - Elsevier Peroxisome proliferator-activated receptor γ (PPARγ) has a role in controlling adipogenesis and
insulin sensitivity. Previous studies have suggested that a common polymorphism
(Pro12Ala) in the PPARγ-2 isoform of this gene may be associated with markers of insulin ... Cited by 60 - Related articles - All 9 versions
CJ Yen, BA Beamer, C Negri, K Silver, KA Brown, … - … and biophysical research …, 1997 - Elsevier Peroxisome proliferator activated receptor-gamma (PPARγ) is a nuclear receptor that regulates
adipocyte differentiation, and possibly lipid metabolism and insulin sensitivity. As such, PPARγ
is a promising candidate gene for several human disorders including obesity and type 2 ... Cited by 268 - Related articles - BL Direct - All 5 versions
SA Cole, BD Mitchell, WC Hsueh, P Pineda, BA … - International journal of …, 2000 - cat.inist.fr Peroxisome proliferator-activated receptors(PPAR) are transcription factors that regulate adipocyte
differentiation and gene expression. We tested the hypothesis that the Pro 12 Ala variant of
PPAR-y 2 is associated with obesity and type 2 diabetes-related traits in 921 subjects ... Cited by 78 - Related articles - BL Direct - All 2 versions
