EA Ryan, JRT Lakey, RV Rajotte, GS Korbutt, T Kin, S … - Diabetes, 2001 - Am Diabetes Assoc Islet transplantation offers the prospect of good glycemic control without major surgical risks.
After our initial report of successful islet transplantation, we now provide further data on 12 type
1 diabetic patients with brittle diabetes or problems with hypoglycemia previous to 1 ... Cited by 549 - Related articles - BL Direct - All 7 versions
AM Shapiro, JRT Lakey, EA Ryan, GS Korbutt, … - New England Journal …, 2000 - content.nejm.org Results All seven patients quickly attained sustained insulin independence after transplantation
of a mean (±SD) islet mass of 11,547±1604 islet equivalents per kilogram of body weight (median
follow-up, 11.9 months; range, 4.4 to 14.9). All recipients required islets from two donor ... Cited by 2397 - Related articles - BL Direct - All 14 versions
- ►diabetesjournals.org EA Ryan, JRT Lakey, BW Paty, S Imes, GS Korbutt, NM … - Diabetes, 2002 - Am Diabetes Assoc Clinical islet transplantation is gaining acceptance as a potential therapy, particularly for subjects
who have labile diabetes or problems with hypoglycemic awareness. The risks of the procedure
and long-term outcomes are still not fully known. We have performed 54 islet ... Cited by 489 - Related articles - BL Direct - All 9 versions
C Ricordi, PE Lacy, EH Finke, BJ Olack, DW Scharp - Diabetes, 1988 - Am Diabetes Assoc We describe an automated method for the isolation of human pancreatic islets. The procedure
meets the following requirements: 1) minimal traumatic action on the islets, 2) continuous digestion
in which the islets that are progressively liberated can be saved from further enzymatic ... Cited by 698 - Related articles - All 5 versions
- ►diabetesjournals.org [PDF] W Bennet, B Sundberg, CG Groth, MD Brendel, D … - Diabetes, 1999 - Am Diabetes Assoc The remarkable difference in success rates between clinical pancreas transplantation and islet
transplanta- tion is poorly understood. Despite the same histocom- patibility barrier and similar
immunosuppressive treat- ments in both transplantation procedures, human intraportal ... Cited by 139 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org EA Ryan, BW Paty, PA Senior, D Bigam, E Alfadhli, NM … - Diabetes, 2005 - Am Diabetes Assoc Islet transplantation can restore endogenous β-cell function to subjects with type 1 diabetes.
Sixty-five patients received an islet transplant in Edmonton as of 1 November 2004. Their mean
age was 42.9 ± 1.2 years, their mean duration of diabetes was 27.1 ± 1.3 years, and 57% ... Cited by 532 - Related articles - All 10 versions
JRT Lakey, GL Warnock, Z Ao, AMJ Shapiro, G … - Transplantation …, 1998 - Elsevier Effective intraductal delivery of the enzyme collagenase into the pancreas is crucial to the subsequent
ability to isolate viable islets. Most clinical islet transplant centers load the enzyme into the pancreas
by retrograde perfusion using a syringe following cannulation of the pancreatic duct.[1] An ... Cited by 140 - Related articles - BL Direct - All 5 versions
E Linetsky, R Bottino, R Lehmann, R Alejandro, L … - Diabetes, 1997 - Am Diabetes Assoc Enzymatic digestion of donor pancreases is a vital step in human and large mammalian islet
isolation. The variable enzymatic activities of different batches of commercially available collagenase
is a major obstacle in achieving reproducibility in islet isolation procedures. In the present ... Cited by 198 - Related articles - BL Direct - All 4 versions
BJ Hering, R Kandaswamy, JV Harmon, JD … - American Journal of …, 2004 - ccmjournal.org American Journal of Transplantation 2004; 4: 390–401 Blackwell Munksgaard ... Copyright C
Blackwell Munksgaard 2004 doi: 10.1046/j.1600-6143.2003.00351.x ... Transplantation of Cultured
Islets from Two-Layer ... Bernhard J. Hering a,∗ , Raja Kandaswamy a , James V. ... Cited by 173 - Related articles - BL Direct - All 6 versions
