R Mallone, E Ortolan, G Baj, A Funaro, S Giunti, E Lillaz … - Diabetes, 2001 - Am Diabetes Assoc Insulin secretion is one of the functions mediated by CD38, a nonlineage pleiotropic cell surface
receptor. The molecule is the target of an autoimmune response, because serum autoantibodies
(aAbs) to CD38 have been detected in diabetic patients. In the healthy Caucasian ... Cited by 25 - Related articles - BL Direct - All 4 versions
R Mallone, E Ortolan, S Pinach, M Volante, M Zanone, … - Diabetologia, 2002 - Springer Aims/hypothesis. Serum anti-CD38 autoantibodies (aAbs) have been reported in 17 to 19% of
patients with long-standing Type I (insulin-dependent) diabe- tes mellitus and Type II
(non-insulin-dependent) dia- betes mellitus. Whether these aAbs are also found in new- ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] C Pupilli, S Giannini, P Marchetti, R Lupi, A Antonelli, F … - Diabetes, 1999 - Am Diabetes Assoc The type II transmembrane glycoprotein CD38 (ADP- ribosyl cyclase/cyclic ADP-ribose
hydrolase) has been proposed as a mediator of insulin secretion from pan- creatic -cells and
as a candidate for autoimmune reac- tions in type 2 diabetes. We evaluated the presence ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org A Antonelli, G Baj, P Marchetti, P Fallahi, N Surico, C … - Diabetes, 2001 - Am Diabetes Assoc CD38 is involved in transmembrane signaling in many cell types; anti-CD38 autoantibodies have
been described in diabetic patients. We tested whether human anti-CD38 antibodies possess
signaling properties by measuring their ability to raise intracellular calcium ([Ca 2+ ] i ) ... Cited by 30 - Related articles - BL Direct - All 5 versions
A Antonelli, T Tuomi, M Nannipieri, P Fallahi, C Nesti, H … - Diabetologia, 2002 - Springer Aims/hypothesis. Autoantibodies against CD38 have been found in some patients with Type
II (non-insulin- dependent) diabetes mellitus and have been shown to stimulate insulin secretion
by cultured human islets. We tested whether this new form of autoimmunity, (i) overlaps ... Cited by 27 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org P Marchetti, A Antonelli, R Lupi, L Marselli, P Fallahi, C … - Diabetes, 2002 - Am Diabetes Assoc Autoantibodies against CD38 (adenosine-5′-diphosphate[ADP]-ribosyl cyclase/cyclic
ADP-ribose hydrolase) have been described in 10–12% of patients with type 2 diabetes. In human
islets, anti-CD38 autoantibodies (CD38Abs) acutely stimulate insulin release (IR) and ... Cited by 6 - Related articles - BL Direct - All 3 versions
NH An, MK Han, C Um, BH Park, BJ Park, HK Kim, … - … and Biophysical Research …, 2001 - Elsevier Cyclic ADP-ribose (cADPR), a product of CD38, has a second messenger role for in intracellular
Ca 2+ mobilization from microsomes of pancreatic islets as well as from a variety of other
cells. ADP-ribosylation of CD38 by ecto-mono ADP-ribosyltransferase in activated T cells ... Cited by 18 - Related articles - BL Direct - All 6 versions
H Okamoto, S Takasawa, K Nata - Diabetologia, 1997 - Springer In answer to the comments of Islam and Berggren concerning our hypothesis on the CD38-cyclic
ADP- ribose (cADPR) signalling system, we will present several lines of evidence that we believe
can explain the discrepancies between their view and ours. ... Glucose is the primary ... Cited by 44 - Related articles - BL Direct - All 4 versions
K Yagui, F Shimada, M Mimura, N Hashimoto, Y Suzuki … - Diabetologia, 1998 - Springer Genetic factors play an important part in the patho- genesis of Type II diabetes mellitus, a heterogeneous
disorder characterised by defects in insulin action as well as insulin secretion [1]. Mutations associated
with Type II diabetes have been identified in the insu- lin [2], insulin receptor [3, 4], ... Cited by 38 - Related articles - BL Direct - All 3 versions
