PPL Chiu, DV Serreze, JS Danska - Diabetes, 2001 - Am Diabetes Assoc Insulin-dependent diabetes (type 1 diabetes) in the NOD mouse is a T-cell–mediated autoimmune
disease. However, B-cells may also play a critical role in disease pathogenesis, as genetically
B-cell–deficient NOD mice (NOD.μMT) have been shown to be protected from type 1 ... Cited by 34 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org H Noorchashm, DJ Moore, LE Noto, N … - The Journal of …, 2000 - Am Assoc Immnol Diabetes in nonobese diabetic (NOD) mice results from the activation of IA g7 -restricted,
islet-reactive T cells. This study delineates several characteristics of NOD CD4 T cell
activation, which, independent of IA g7 , are likely to promote a dysregulated state of ... Cited by 47 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org SAW Greeley, DJ Moore, H Noorchashm, LE … - The Journal of …, 2001 - Am Assoc Immnol Despite the impressive protection of B cell-deficient (µMT -/- ) nonobese diabetic (NOD) mice
from spontaneous diabetes, existence of mild pancreatic islet inflammation in these mice indicates
that initial autoimmune targeting of cells has occurred. Furthermore, µMT -/- NOD mice ... Cited by 33 - Related articles - BL Direct - All 4 versions
PA Silveira, E Johnson, HD Chapman, T … - European journal of …, 2002 - interscience.wiley.com B lymphocytes partially contribute to autoimmune type 1 diabetes (T1D) as a subset of APC with
a preferential ability to trigger pathogenic CD4 T cells. We hypothesized that this resulted fromthe
unique ability of B lymphocytes to take up pancreatic cell proteins through Ig mediated ... Cited by 56 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org H Noorchashm, YK Lieu, N Noorchashm, SY … - The Journal of …, 1999 - Am Assoc Immnol B cell-deficient nonobese diabetic (NOD) mice are protected from the development of spontaneous
autoimmune diabetes, suggesting a requisite role for Ag presentation by B lymphocytes for the
activation of a diabetogenic T cell repertoire. This study specifically examines the ... Cited by 98 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org C Hulbert, B Riseili, M Rojas, JW … - The Journal of Immunology, 2001 - Am Assoc Immnol Type I diabetes mellitus (TIDM) is an autoimmune disorder characterized by T cell-mediated
destruction of insulin-producing cells in the pancreas. In the nonobese diabetic (NOD) model
of TIDM, insulitis and diabetes are dependent on the presence of B lymphocytes; ... Cited by 39 - Related articles - BL Direct - All 3 versions
M Yang, B Charlton, AM Gautam - Journal of Autoimmunity, 1997 - Elsevier Insulin-dependent diabetes mellitus (IDDM) is believed to be an autoimmune disease that results
from autoimmune destruction of the insulin-secreting β-cells of the pancreas. In addition to a
lymphocytic infiltration (insulitis) of the islets, patients with IDDM have autoantibodies ... Cited by 47 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org PA Silveira, J Dombrowsky, E Johnson, HD … - The Journal of …, 2004 - Am Assoc Immnol One mechanism whereby B cells contribute to type 1 diabetes in nonobese diabetic (NOD) mice
is as a subset of APCs that preferentially presents MHC class II-bound pancreatic cell Ags to
autoreactive CD4 T cells. This results from their ability to use cell surface Ig to specifically ... Cited by 33 - Related articles - BL Direct - All 4 versions
- ►lambris.net [PDF] H Noorchashm, DJ Moore, YK Lieu, N Noorchashm, A … - Cellular Immunology, 1999 - Elsevier B lymphocytes are required for diabetogenesis in nonobese diabetic (NOD) mice. The complement
component of the innate immune system regulates B cell activation and tolerance through complement
receptors CR1/CR2. Thus, it is important to assess the contribution of complement ... Cited by 24 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org H Braley-Mullen, S Yu - The Journal of Immunology, 2000 - Am Assoc Immnol B cells are known to play an important role in the pathogenesis of several autoimmune
diseases. NOD.H-2h4 mice develop spontaneous autoimmune thyroiditis (SAT) and anti-mouse
thyroglobulin (MTg) autoantibodies, the levels of which correlate closely with the severity ... Cited by 34 - Related articles - BL Direct - All 2 versions
