- ►diabetesjournals.org H Hui, C Wright, R Perfetti - Diabetes, 2001 - Am Diabetes Assoc Glucagon-like peptide-1 (GLP-1) is an incretin hormone capable of restoring normal glucose
tolerance in aging glucose-intolerant Wistar rats. Whether the antidiabetic properties of
GLP-1 are exclusively due to its insulin secretory activity remains to be determined. A ... Cited by 172 - Related articles - BL Direct - All 5 versions
J Zhou, X Wang, MA Pineyro, JM Egan - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc In this article, we show that glucagon-like peptide 1 (GLP-1) can induce AR42J cells to differentiate
into insulin, pancreatic polypeptide, and glucagon-positive cells. In their natural state, these
cells, which are derived from a chemically induced pancreatic tumor, possess exocrine ... Cited by 236 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] DA Stoffers, TJ Kieffer, MA Hussain, DJ Drucker, S … - Diabetes, 2000 - Am Diabetes Assoc Diabetes is caused by a failure of the pancreas to pro- duce insulin in amounts sufficient to meet
the body's needs. A hallmark of diabetes is an absolute (type 1) or relative (type 2) reduction
in the mass of pancreatic ß-cells that produce insulin. Mature ß-cells have a life- span of ... Cited by 341 - Related articles - BL Direct - All 4 versions
- ►endojournals.org R Perfetti, J Zhou, ME Doyle, JM Egan - Endocrinology, 2000 - Endocrine Soc Glucose homeostasis in mammals is maintained by insulin secretion from the ß-cells of the islets
of Langerhans. Type 2 diabetes results either from primary ß-cell failure alone and/or a failure
to secrete enough insulin to overcome insulin resistance. Here, we show that continuous ... Cited by 191 - Related articles - BL Direct - All 3 versions
- ►endojournals.org EJ Abraham, CA Leech, JC Lin, H Zulewski, JF … - Endocrinology, 2002 - Endocrine Soc Glucagon-like peptide-1 (GLP-1) is an intestinal incretin hormone, derived from the processing
of proglucagon, that exerts insulinotropic actions on insulin-producing pancreatic islet
ß-cells. Recently GLP-1 was shown to stimulate the growth and differentiation ... Cited by 238 - Related articles - BL Direct - All 4 versions
J Buteau, R Roduit, S Susini, M Prentki - Diabetologia, 1999 - Springer Glucagon-like peptide-1-(7±36)amide (GLP-1) is se- creted by the enteroendocrine L-cells in
response to fat meals and carbohydrates [1, 2]. It is a potent glu- coincretin hormone which acts
as a competence fac- tor in determining the ability of the beta-cell to re- spond to glucose ... Cited by 236 - Related articles - BL Direct - All 4 versions
R Perfetti - US Patent App. 09/920,868, 2001 - Google Patents US 20030113300A1 (19) United States (12) Patent Application Publication (io> Pub. NO.: US
2003/0113300 Al Perfetti (43) Pub. Date: Jun. 19,2003 (54) HUMAN GLUCOSE-DEPENDENT
INSULIN-SECRETING CELL LINE (75) Inventor: Riccardo Perfetti, Los Angeles, CA (US) ... Related articles - All 7 versions
R Perfetti, H Hui - US Patent App. 10/097,230, 2002 - Google Patents US 20030186436A1 (19) United States (12) Patent Application Publication (io> Pub. NO.: US
2003/0186436 Al Perfetti et al. (43) Pub. Date: Oct. 2,2003 (54) GLUCOSE-DEPENDENT
INSULIN-SECRETING CELLS TRANSFECTED WITH A NUCLEOTIDE SEQUENCE ... Related articles - All 4 versions
- ►endojournals.org L Farilla, H Hui, C Bertolotto, E Kang, A Bulotta, U Di … - Endocrinology, 2002 - Endocrine Soc A constant remodeling of islet cell mass mediated by proliferative and apoptotic stimuli ensures
a dynamic response to a changing demand for insulin. In this study, we investigated the effect
of glucagon-like peptide-1 (GLP-1) in Zucker diabetic rats, an animal model in which the ... Cited by 193 - Related articles - BL Direct - All 6 versions
- ►endojournals.org A Edvell, P Lindstrom - Endocrinology, 1999 - Endocrine Soc Pancreatic islets from obese hyperglycemic mice are large and contain a high proportion of normally
functioning ß-cells. We have previously shown that young obese mice have an elevated ß-cell
proliferation rate at 3 weeks of age. We now wanted to investigate possible factors ... Cited by 92 - Related articles - BL Direct - All 6 versions
