AM Efanov, SV Zaitsev, HJ Mest, A Raap, IB … - Diabetes, 2001 - Am Diabetes Assoc The insulinotropic activity of the novel imidazoline compound BL11282 was
investigated. Intravenous administration of BL11282 (0.3 mg · kg –1 · min
–1 ) to anesthetized rats did not change blood glucose and insulin levels ... Cited by 41 - Related articles - BL Direct - All 6 versions
M Høy, HL Olsen, HS Andersen, K Bokvist, K … - European journal of pharmacology, 2003 - Elsevier We have investigated the effects of the novel imidazoline compound (+)-2-(2-(4,5
-dihydro-1H-imidazol-2-yl)-thiopene-2-yl-ethyl)-pyridine (NNC77-0074) on
stimulus-secretion coupling in isolated pancreatic α- and β-cells. ... Cited by 17 - Related articles - All 5 versions
SLF Chan, M Mourtada, NG Morgan - Diabetes, 2001 - Am Diabetes Assoc Efaroxan, like several other imidazoline reagents, elicits a glucose-dependent
increase in insulin secretion from pancreatic β-cells. This response has been
attributed to efaroxan-mediated blockade of K ATP channels, with the ... Cited by 31 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org S Efendic, AM Efanov, PO Berggren, SV … - Diabetes, 2002 - Am Diabetes Assoc The imidazoline RX871024 increased basal- and glucose-stimulated insulin release
in vitro and in vivo. The compound inhibited activity of ATP-sensitive K +
channels as well as voltage-gated K + channels, which led to membrane ... Cited by 26 - Related articles - BL Direct - All 4 versions
SV Zaitsev, AM Efanov, IB Efanova, O Larsson … - Diabetes, 1996 - Am Diabetes Assoc A novel imidazoline compound, RX871024, was used to investigate the mechanisms
by which imidazoline derivatives promote insulin secretion in rat pancreatic
beta-cells and HIT T15 cells. RX871024 stimulated insulin release from rat ... Cited by 94 - Related articles - BL Direct - All 7 versions
SV Zaitsev, AM Efanov, A Raap, IB Efanova, … - Annals of the New York Academy of Sciences, 1999 - ncbi.nlm.nih.gov The imidazoline compound RX871024 glucose-dependently potentiates the release of
insulin in pancreatic islets and beta-cell lines. This activity of the compound
is not related to its action by stimulating alpha 2-adrenoceptors and I1- ... Cited by 15 - Related articles - All 3 versions
NG Morgan, SLF Chan - Current pharmaceutical design, 2001 - ingentaconnect.com Page 1. Current Pharmaceutical Design, 2001, 7, 1413-1431 1413 Imidazoline
Binding Sites in the Endocrine Pancreas: Can They Fulfil ... Cited by 28 - Related articles - BL Direct - All 5 versions
I Rustenbeck, C Herrmann, P Ratzka, A … - Naunyn-Schmiedeberg's archives of pharmacology, 1997 - Springer Abstract To elucidate the β-cytotropic effect of imidazo- line compounds their
inhibitory effect on ATP-dependent K + channels (K ATP channels) in pancreatic
B-cells was compared with their binding to membranes from insulin- ... Cited by 30 - Related articles - BL Direct - All 3 versions
- ►physiology.org AM Efanov, IB Appelskog, SM Abdel-Halim, A … - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc The insulinotropic activity of the imidazoline derivative RX871024 was compared
in pancreatic islets from nondiabetic Wistar rats and spontaneously diabetic
Goto-Kakizaki (GK) rats. RX871024 significantly stimulated insulin ... Cited by 13 - Related articles - BL Direct - All 4 versions
AM Efanov, M Høy, R Bränström, SV … - Biochemical and Biophysical Research …, 2001 - Elsevier Effects of the imidazoline compound RX871024 on cytosolic free Ca 2+
concentration ([Ca 2+ ] i ) and insulin secretion in pancreatic β-cells from
SUR1 deficient mice have been studied. In β-cells from wild-type mice ... Cited by 14 - Related articles - BL Direct - All 5 versions
