J He, S Watkins, DE Kelley - Diabetes, 2001 - Am Diabetes Assoc In obesity and type 2 diabetes, skeletal muscle has been observed to have a reduced oxidative
enzyme activity, increased glycolytic activity, and increased lipid content. These metabolic characteristics
are related to insulin resistance of skeletal muscle and are factors potentially related to ... Cited by 171 - Related articles - BL Direct - All 4 versions
- ►physiology.org JA Simoneau, DE Kelley - Journal of Applied Physiology, 1997 - Am Physiological Soc A GOOD DEAL OF THE FUNCTIONAL DIVERSITY of skeletal muscle derives from differences
of fiber type distribution, and this also helps determine metabolic diversity of skeletal muscle.
Insulin-stimulated metabolism in skeletal muscle is influenced by fiber type (10). In regard ... Cited by 171 - Related articles - BL Direct - All 5 versions
BH Goodpaster, R Theriault, SC Watkins, DE Kelley - Metabolism, 2000 - Elsevier The triglyceride content of skeletal muscle samples determined by lipid extraction correlates
with the severity of insulin-resistant glucose metabolism in muscle. To determine whether this
reflects increased triglyceride within muscle fibers and to test the-hypothesis that the lipid ... Cited by 158 - Related articles - BL Direct - All 3 versions
DE Kelley, J He, EV Menshikova, VB Ritov - Diabetes, 2002 - Am Diabetes Assoc Skeletal muscle is strongly dependent on oxidative phosphorylation for energy production. Because
the insulin resistance of skeletal muscle in type 2 diabetes and obesity entails dysregulation
of the oxidation of both carbohydrate and lipid fuels, the current study was undertaken to ... Cited by 533 - Related articles - BL Direct - All 4 versions
K Levin, H Daa Schroeder, FP Alford, H Beck-Nielsen - Diabetologia, 2001 - Springer Over the last decade, the role of excessive lipid avail- ability in the pathogenesis of Type II
(non-insulin-de- pendent) diabetes mellitus has been the subject of in- creasing attention
[1ą4]. It has recently been suggest- ed that the disease could be better characterized in ... Cited by 75 - Related articles - BL Direct - All 3 versions
- ►fasebj.org JA SIMONEAU, J VEERKAMP… - The FASEB Journal, 1999 - FASEB A number of biochemical defects have been identified in glucose metabolism within skeletal
muscle in obesity, and positive effects of weight loss on insulin resistance are also well
established. Less is known about the capacity of skeletal muscle for the metabolism of ... Cited by 218 - Related articles - BL Direct - All 5 versions
DIW Phillips, S Caddy, V Ilic, BA Fielding, KN Frayn, AC … - Metabolism, 1996 - Elsevier Intracellular triglyceride (TG) is an important energy source for skeletal muscle. However, recent
evidence suggests that if muscle contains abnormally high TG stores its sensitivity to insulin may
be reduced, and this could predispose to type II diabetes. To test this hypothesis, we ... Cited by 250 - Related articles - BL Direct - All 4 versions
- ►physiology.org DE Kelley, B Goodpaster, RR Wing, JA … - American Journal of …, 1999 - Am Physiological Soc The current study was undertaken to investigate fatty acid metabolism by skeletal muscle to examine
potential mechanisms that could lead to increased muscle triglyceride in obesity. Sixteen lean
and 40 obese research volunteers had leg balance measurement of glucose and free ... Cited by 365 - Related articles - All 5 versions
VB Ritov, EV Menshikova, J He, RE Ferrell, BH … - Diabetes, 2005 - Am Diabetes Assoc The current study addresses a novel hypothesis of subcellular distribution of mitochondrial dysfunction
in skeletal muscle in type 2 diabetes. Vastus lateralis muscle was obtained by percutaneous
biopsy from 11 volunteers with type 2 diabetes; 12 age-, sex-, and weight-matched obese ... Cited by 194 - Related articles - All 6 versions
DA Pan, S Lillioja, AD Kriketos, MR Milner, LA Baur, C … - Diabetes, 1997 - Am Diabetes Assoc In animal studies, increased amounts of triglyceride associated with skeletal muscle (mTG) correlate
with reduced skeletal muscle and whole body insulin action. The aim of this study was to test
this relationship in humans. Subjects were 38 nondiabetic male Pima Indians (mean age ... Cited by 619 - Related articles - BL Direct - All 4 versions
