BV Costanzo, V Trischitta, R Di Paola, D Spampinato, A … - Diabetes, 2001 - Am Diabetes Assoc When overexpressed, the membrane glycoprotein PC-1 may play a role in human insulin resistance
through the inhibition of insulin receptor (IR) autophosphorylation. A PC-1 variant (K 121 Q, with
lysine 121 replaced by glutamine) is also associated with whole-body insulin resistance ... Cited by 76 - Related articles - BL Direct - All 5 versions
A Pizzuti, L Frittitta, A Argiolas, R Baratta, ID … - DIABETES-NEW …, 1999 - Am Diabetes Assoc The genes responsible for insulin resistance are poorly defined. Plasma cell differentiation antigen
(PC-1) gly- coprotein inhibits insulin receptor signaling and is associated with insulin
resistance. We describe here a novel polymorphism in exon 4 of the PC-1 gene (K121Q) ... Cited by 147 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] SK Rasmussen, SA Urhammer, A Pizzuti, SM Echwald, … - Diabetes, 2000 - Am Diabetes Assoc The human plasma-cell membrane differentiation anti- gen-1 (PC-1) has been shown to inhibit
insulin receptor tyrosine kinase activity. Recently, a K121Q polymor- phism in the human
PC-1 gene was found in a Sicilian population and was shown to be strongly associated ... Cited by 67 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] BA Maddux, ID Goldfine - Diabetes, 2000 - Am Diabetes Assoc Plasma cell membrane glycoprotein-1 (PC-1) inhibits insulin receptor (IR) tyrosine kinase activity
and sub- sequent cellular signaling. PC-1 content is elevated in fibroblasts, muscle, and adipose
tissue from insulin- resistant subjects, and its elevation correlates with in vivo insulin ... Cited by 108 - Related articles - BL Direct - All 7 versions
HF Gu, P Almgren, E Lindholm, L Frittttta, A … - DIABETES-NEW …, 2000 - Am Diabetes Assoc We studied whether there is an association between the single nucleotide polymorphism
c.533A>C (K121Q) in the glycoprotein PC-1 gene and features of the metabolic syn- drome in
case-control and intrafamily association studies in 922 subjects from Finland and ... Cited by 93 - Related articles - BL Direct - All 4 versions
A Kubaszek, J Pihlajamäki, P Karhapää, I … - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—The 121Q allele (genotypes K121Q and Q121Q) compared with the K121K genotype
was related to higher fasting insulin levels (group I: 69.6 ± 45.6 vs. 51.9 ± 28.4 pmol/l [mean ±
SD], P = 0.050; group II: 66.6 ± 38.8 vs. 53.8 ± 26.6 pmol/l, P = 0.009). In group I, subjects ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►endojournals.org L Frittitta, R Baratta, D Spampinato, R Di Paola, … - Journal of Clinical …, 2001 - Endocrine Soc PC-1 is a membrane glycoprotein that impairs insulin receptor function. Its K121Q polymorphism
is a genetic determinant of insulin resistance. We investigated whether the PC-1 gene modulates
insulin sensitivity independently of weight status (ie both in nonobese and obese ... Cited by 37 - Related articles - BL Direct - All 5 versions
N Abate, M Chandalia, P Satija, B Adams-Huet, SM … - Diabetes, 2005 - Am Diabetes Assoc Genetic susceptibility modulates the impact of obesity on risk for type 2 diabetes. The present
study evaluates the role of ENPP1 K121Q polymorphism in prediction of type 2 diabetes in three
populations that differ in susceptibility to diabetes and environmental exposure. The three ... Cited by 74 - Related articles - All 9 versions
S Bacci, O Ludovico, S Prudente, YY Zhang, R Di … - Diabetes, 2005 - Am Diabetes Assoc Insulin resistance (IR) is pathogenic for type 2 diabetes and coronary artery disease (CAD). The
K121Q polymorphism of the ENPP1/PC-1 gene is associated with IR. Our aim was to investigate
the role of the 121Q variant on the risk of type 2 diabetes and CAD. Nondiabetic control ... Cited by 54 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org J Bochenski, G Placha, K Wanic, M Malecki, J Sieradzki … - Diabetes, 2006 - Am Diabetes Assoc The K121Q polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1
(ENPP1) is associated with type 2 diabetes and obesity. The possibility of other ENPP1 polymorphisms
influencing these phenotypes has received little attention. Our aim was to examine the ... Cited by 35 - Related articles - BL Direct - All 6 versions
