- ►diabetesjournals.org M Stumvoll, HG Wahl, K Löblein, R Becker, F Machicao … - Diabetes, 2001 - Am Diabetes Assoc The Pro12Ala polymorphism of the peroxisome proliferator–activated receptor (PPAR)-γ 2 is
associated with reduced transcriptional activity in vitro and increased insulin sensitivity in
humans in vivo. The mechanism by ... Cited by 88 - Related articles - BL Direct - All 4 versions
M Koch, K Rett, E Maerker, A Volk, K Haist, M Deninger … - Diabetologia, 1999 - Springer The peroxisome proliferator activated receptors (PPAR) are members of the nuclear hormone recep- tor
superfamily which act as transcription factors reg- ulating important mechanisms in adipocyte
differen- tiation. Natural ligands ... Cited by 87 - Related articles - BL Direct - All 4 versions
S Jacob, M Stumvoll, R Becker, M Koch, M … - Horm Metab …, 2000 - thieme-connect.com Recently, a highly prevalent polymorphism of the PPAR?2-receptor (Pro12Ala) was described and found
to be associated with reduced transcriptional activity. Both human and animal studies suggested that
this polymorphism may be associated ... Cited by 54 - Related articles - BL Direct - All 2 versions
BA Beamer, CJ Yen, RE Andersen, D Muller, … - DIABETES-NEW …, 1998 - Am Diabetes Assoc T he nuclear receptor, peroxisome proliferator- act i- vated receptor- ( P PA R - ), is an important
regula- tor of adipocyte differentiation and a modulator of intracellular insulin-signaling events
(1). PPA R - mRNA expression in ... Cited by 210 - Related articles - BL Direct - All 5 versions
SA Cole, BD Mitchell, WC Hsueh, P Pineda, BA … - International journal of …, 2000 - cat.inist.fr Peroxisome proliferator-activated receptors(PPAR) are transcription factors that regulate adipocyte
differentiation and gene expression. We tested the hypothesis that the Pro 12 Ala variant of PPAR-y
2 is associated with obesity and ... Cited by 78 - Related articles - BL Direct - All 2 versions
BJ Nicklas, EFC van Rossum, DM Berman, AS Ryan, … - Diabetes, 2001 - Am Diabetes Assoc This study determined the effects of the peroxisome proliferator–activated receptor (PPAR)-γ2
Pro12Ala variant on body composition and metabolism and the magnitude of weight regain in 70
postmenopausal women (BMI 25–40 ... Cited by 87 - Related articles - BL Direct - All 5 versions
- ►endojournals.org R Valve, K Sivenius, R Miettinen, J Pihlajamaki, … - Journal of Clinical …, 1999 - Endocrine Soc Peroxisome proliferator-activated receptor- (PPAR ) is a nuclear receptor that regulates adipocyte
differentiation. Variations in the PPAR gene may affect the function of the PPAR and, therefore,
body adipocity. We investigated the ... Cited by 180 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org H Mori, H Ikegami, Y Kawaguchi, S Seino, N Yokoi, J … - Diabetes, 2001 - Am Diabetes Assoc The allele frequencies for a Pro 12 →Ala substitution in peroxisome proliferator–activated
receptor-γ differ among ethnic groups, and its relationship with diabetes and associated diseases
is controversial. The prevalence of ... Cited by 163 - Related articles - BL Direct - All 5 versions
J Masugi, Y Tamori, H Mori, T Koike, M Kasuga - Biochemical and Biophysical …, 2000 - Elsevier Peroxisome proliferator-activated receptor-γ (PPARγ) is a member of the nuclear hormone receptor
superfamily of transcription factors and appears to be a key regulator of adipogenesis. Members of
the thiazolidinedione class of ... Cited by 111 - Related articles - BL Direct - All 5 versions
O Tschritter, A Fritsche, N Stefan, M Haap, C Thamer, O … - Metabolism, 2003 - Elsevier The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPARγ 2 ) is
associated with reduced risk for type 2 diabetes. Although increased insulin sensitivity of glucose
disposal and lipolysis has been ... Cited by 21 - Related articles - All 10 versions
