M Stumvoll, A Fritsche, A Volk, N Stefan, A … - Diabetes, 2001 - Am Diabetes Assoc The Gly972Arg polymorphism in the insulin receptor substrate (IRS)-1 was found
in some studies to have a higher prevalence in type 2 diabetic subjects than in
control subjects. Previously, transfection of IRS-1 with this polymorphism ... Cited by 58 - Related articles - BL Direct - All 4 versions
P Marchetti, R Lupi, M Federici, L Marselli, M … - Diabetes, 2002 - Am Diabetes Assoc Type 2 (non–insulin-dependent) diabetes results from decreased insulin action
in peripheral target tissues (insulin resistance) and impaired pancreatic
β-cell function. These defects reflect both genetic components and ... Cited by 67 - Related articles - BL Direct - All 5 versions
- ►nih.gov O Porzio, M Federici, ML Hribal, D Lauro, D … - Journal of Clinical Investigation, 1999 - Am Soc Clin Investig Recent studies have identified several polymorphisms in the human insulin
receptor substrate-1 (IRS-1) gene. The most prevalent IRS-1 variant, a Gly→Arg
change at the codon 972, has been reported to be increased in prevalence ... Cited by 116 - Related articles - BL Direct - All 8 versions
- ►fasebj.org [PDF] M Federici, ML Hribal, M Ranalli, L Marselli, … - The FASEB Journal, 2000 - FASEB * Laboratory of Molecular Medicine, Department of Internal Medicine, University
of Rome-«Tor Vergata», 00133 Rome, Italy; †IDI-IRCCS, Biochemistry
Laboratory, c/o Department of Experimental Medicine, University of ... Cited by 73 - Related articles - All 3 versions
MG Baroni, M Arca, F Sentinelli, R Buzzetti, F … - Diabetologia, 2001 - Springer Insulin resistance is generally recognised as a core factor in the pathogenesis
of common disorders such as Type II (non-insulin-dependent) diabetes mellitus,
hypertension and premature atherosclerosis. Familial transmission and ... Cited by 35 - Related articles - BL Direct - All 3 versions
GA Hitman, K Hawrami, MI McCarthy, M … - Diabetologia, 1995 - Springer Summary Variations in the coding regions of the in- sulin receptor substrate-1
(IRS-1) gene have recently been suggested to contribute to the susceptibility of
non-insulin-dependent diabetes mellitus (NIDDM). The purpose of this study ... Cited by 83 - Related articles - BL Direct - All 4 versions
- ►endojournals.org ML Hribal, M Federici, O Porzio, D Lauro, P … - Journal of Clinical Endocrinology & Metabolism, 2000 - Endocrine Soc Molecular scanning of insulin receptor substrate-1 (IRS-1) revealed several
amino acid substitutions. The most common IRS-1 variant, a Gly to Arg 972
change, is more prevalent among type 2 diabetic patients. In this study we ... Cited by 54 - Related articles - BL Direct - All 4 versions
Y Zhang, N Wat, IM Stratton, MG Warren-Perry … - Diabetologia, 1996 - Springer The common form of late-onset non-insulin-depen- dent diabetes mellitus (NIDDM)
is a complex disor- der in which at least two major defects contribute to the
pathophysiology of the phenotype: insulin defi- ciency and insulin ... Cited by 88 - Related articles - BL Direct - All 13 versions
JO Clausen, T Hansen, C Bjørbaek, SM … - Lancet, 1995 - ncbi.nlm.nih.gov We previously discovered two aminoacid polymorphisms in codons 513 and 972 of
the protein insulin receptor substrate-1 (IRS-1), which is important in cellular
insulin action. We have investigated whether these polymorphisms are ... Cited by 162 - Related articles - BL Direct - All 4 versions
