- ►diabetesjournals.org J Diez, Y Park, M Zeller, D Brown, D Garza, C Ricordi, J … - Diabetes, 2001 - Am Diabetes Assoc Type 1 diabetes results from the autoimmune destruction of pancreatic ß-cells in genetically susceptible
individuals. Growing evidence suggests that genetically determined variation in the expression
of self-antigens in thymus may affect the shaping of the T-cell repertoire and susceptibility ... Cited by 50 - Related articles - BL Direct - All 5 versions
- ►uchc.edu [PDF] YS Park, E Kawasaki, K Kelemen, L Yu, MR Schiller, M … - Diabetologia, 2000 - Springer [2±6], carboxypepetidase H [7], the glycolipid GM2±1 [8], islet cell autoantigen 69 [9] and the
pro- tein tyrosine phosphatase (PTP)-like proteins ICA512 [10±14] and phogrin (IA-2b) [15,
16]. Auto- antibodies (AA) as such have yet to be shown to play a major part in the ... Cited by 23 - Related articles - BL Direct - All 4 versions
[CITATION] Insulin gene expression and imprinting in pancreas and lymphoid organs
O Werdelin, U Cordes, T Jensen - Scandinavian journal of …, 1998 - interscience.wiley.com Herein we present the case for the existence of a thymic cortical epithelial cell that possesses
an unusual gene transcription. It produces tissue-specific proteins that have their usual physiological
functions outside the thymus and presents them, as well as household proteins, to the ... Cited by 33 - Related articles - BL Direct - All 3 versions
MK Brimnes, T Jensen, TN Jørgensen, BK Michelsen, … - Journal of Autoimmunity, 2002 - Elsevier Insulin is a predominant autoantigen in IDDM in man and the NOD mouse. Failure of negative
selection of diabetogenic T cells in thymus may be an important pre-disposing cause of the
disease. To obtain insight into negative selection against such T-cell clones the thymic ... Cited by 16 - Related articles - BL Direct - All 5 versions
- ►nih.gov A Pugliese, D Brown, D Garza, D … - Journal of Clinical …, 2001 - Am Soc Clin Investig Recent reports indicate that genes with tissue-restricted expression, including those encoding
the type 1 diabetes autoantigens insulin, glutamic acid decarboxylase (GAD), and the
tyrosine-phosphatase-like protein IA-2 (or ICA512), are transcribed in the thymus. The ... Cited by 105 - Related articles - BL Direct - All 9 versions
- ►jimmunol.org M Sospedra, X Ferrer-Francesch, O … - The Journal of …, 1998 - Am Assoc Immnol The role of the thymus in the induction of tolerance to peripheral antigens is not yet well
defined. One impending question involves how the thymus can acquire the diversity of peripheral
nonthymic self-Ags for the process of negative selection. To investigate whether ... Cited by 128 - Related articles - BL Direct - All 4 versions
- ►nih.gov K Thébault-Baumont, D Dubois-Laforgue, … - Journal of Clinical …, 2003 - Am Soc Clin Investig Accumulating evidence favors a role for proinsulin as a key autoantigen in diabetes. In the
mouse, two proinsulin isoforms coexist. Most studies point to proinsulin 2 as the major isoform
recognized by T cells in the NOD mouse. We studied mice in which a null proinsulin 2 ... Cited by 102 - Related articles - BL Direct - All 6 versions
- ►endojournals.org M Throsby, F Homo-Delarche, D Chevenne, R Goya, M … - Endocrinology, 1998 - Endocrine Soc The expression of preproinsulin (ppIns), proglucagon, prosomatostatin, and propancreatic polypeptide
was investigated in thymic extracts, thymic cells, and thymic cell lines from C57BL/6 mice by
RT-PCR. The expression of pancreatic hormones was similar in thymic extracts taken ... Cited by 79 - Related articles - BL Direct - All 5 versions
