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Scholar Results 1 - 10 of about 101 related to Lynn: Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic.... (0.12 sec) 

Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty …

- diabetesjournals.org
FC Lynn, N Pamir, EHC Ng, CHS McIntosh, TJ … - Diabetes, 2001 - Am Diabetes Assoc
Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone that is
released postprandially from the small intestine and acts in concert with
glucagon-like peptide (GLP)-1 to potentiate glucose-induced insulin ...
Cited by 90 - Related articles - BL Direct - All 4 versions

The pathogenesis of NIDDM involves a defective expression of the GIP receptor


JJ Holst, J Gromada, MA Nauck - Diabetologia, 1997 - Springer
Carbohydrate ingestion causes the release of two in- sulinotropic intestinal
hormones, glucose-dependent insulinotropic polypeptide (GIP) [1] and glucagon-
like peptide-1 (GLP-1) [2]. GIP is mainly released from the duodenum, and ...
Cited by 68 - Related articles - BL Direct - All 3 versions

Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of …


JJ Meier, K Hücking, JJ Holst, CF Deacon, … - Diabetes, 2001 - Am Diabetes Assoc
In patients with type 2 diabetes, gastric inhibitory polypeptide (GIP) has lost
much of its insulinotropic activity. Whether this is similar in first-degree
relatives of patients with type 2 diabetes is unknown. A total of 21 first- ...
Cited by 102 - Related articles - BL Direct - All 5 versions

Identification of two missense mutations in the GIP receptor gene: a functional study and …


A Kubota, Y Yamada, T Hayami, K Yasuda, Y … - Diabetes, 1996 - Am Diabetes Assoc
Gastric inhibitory polypeptide (GIP) potently stimulates insulin secretion from
pancreatic islets in the presence of glucose as an incretin. Because the
insulinotropic effect of GIP is reduced in NIDDM, it should be clarified ...
Cited by 37 - Related articles - BL Direct - All 5 versions

A novel pathway for regulation of glucose-dependent insulinotropic polypeptide receptor …

- fasebj.org [PDF] 
FC Lynn, SA Thompson, JA Pospisilik, JA … - The FASEB Journal, 2002 - FASEB
The FASEB Journal express article 10.1096/fj.02-0243fje. Published online
November 15, 2002. ... A novel pathway for regulation of glucose-dependent ...
Francis C. Lynn, Stephen A. Thompson, J. Andrew Pospisilik, Jan A. Ehses, ...
Cited by 29 - Related articles - BL Direct - All 6 versions

Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide ( …

- nih.gov [PDF] 
CC Tseng, TJ Kieffer, LA Jarboe, TB Usdin, … - Journal of Clinical Investigation, 1996 - pubmedcentral.nih.gov
J. Clin. Invest. © The American Society for Clinical Investigation, Inc.
0021-9738/96/12/2440/06 $2.00 Volume 98, Number 11, December 1996, 2440–2445
... Postprandial Stimulation of Insulin Release by Glucose-dependent ...
Cited by 83 - Related articles - BL Direct - All 7 versions

Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral …

- endojournals.org
JT Lewis, B Dayanandan, JF Habener, TJ … - Endocrinology, 2000 - Endocrine Soc
A novel GIP receptor antagonist was developed to evaluate the acute role of
glucose-dependent insulinotropic polypeptide (GIP) in the insulin response to
oral glucose in rats. Antisera to an extracellular epitope of the GIP ...
Cited by 58 - Related articles - BL Direct - All 3 versions

Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric …

- pnas.org
K Miyawaki, Y Yamada, H Yano, H Niwa, N Ban, … - Proceedings of the National Academy of Sciences, 1999 - National Acad Sciences
Mice with a targeted mutation of the gastric inhibitory polypeptide (GIP)
receptor gene (GIPR) were generated to determine the role of GIP as a mediator
of signals from the gut to pancreatic β cells. GIPR−/− mice have ...
Cited by 220 - Related articles - BL Direct - All 9 versions

Effect of porcine gastric inhibitory polypeptide on beta-cell function in type I and type II …


T Krarup, N Saurbrey, AJ Moody, C Kühl, S … - Metabolism: clinical and experimental, 1987 - ncbi.nlm.nih.gov
The effect of highly purified natural porcine GIP on C-peptide release was
examined in six type I (insulin-dependent) diabetics (IDD) with residual
beta-cell function, six type II non-insulin-dependent) diabetics (NIDD), ...
Cited by 41 - Related articles - All 3 versions

Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide …


K Almind, L Ambye, SA Urhammer, T Hansen, … - Diabetologia, 1998 - Springer
So far, there is no clarification of the potential role of the two incretins,
gastric inhibitory polypeptide/glu- cose-dependent insulinotropic polypeptide
(GIP) and glucagon-like peptide-1 (GLP-1) in the patho- genesis of Type II ...
Cited by 35 - Related articles - BL Direct - All 3 versions


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