- ►diabetesjournals.org DT Finegood, MD McArthur, D Kojwang, MJ Thomas, … - Diabetes, 2001 - Am Diabetes Assoc The evolution of diabetes in the male leptin receptor−deficient (fa/fa) Zucker diabetic fatty
(ZDF) rat is associated with disruption of normal islet architecture, β-cell degranulation, and increased
β-cell death. It is unknown whether these changes precede or develop as a result of the ... Cited by 232 - Related articles - BL Direct - All 4 versions
M Higa, YT Zhou, M Ravazzola, D … - Proceedings of the …, 1999 - National Acad Sciences To determine whether the antidiabetic action of troglitazone (TGZ), heretofore attributed to insulin
sensitization, also involves protection of β cells from lipoapoptosis, we treated prediabetic Zucker
Diabetic Fatty rats with 200 mg/kg per day of TGZ. Their plasma-free fatty acids and ... Cited by 182 - Related articles - BL Direct - All 7 versions
M Shimabukuro, YT Zhou, Y Lee, RH Unger - Journal of Biological Chemistry, 1998 - ASBMB The thiazolidinedione compound troglitazone, which is used to treat non-insulin-dependent diabetes
mellitus (NIDDM) in man, is also effective in the adipogenic NIDDM of Zucker diabetic fatty
(ZDF) rats. To test the “lipotoxicity hypothesis,” which attributes the beta cell dysfunction of ... Cited by 210 - Related articles - BL Direct - All 4 versions
- ►physiology.org R Lupi, S Del Guerra, L Marselli, M … - American Journal of …, 2004 - Am Physiological Soc Peroxisome proliferator-activated receptors (PPARs) are a subgroup of the superfamily of nuclear
receptors, with three distinct main types: , and (subdivided into 1 and 2 ). Recently, the presence
of PPAR has been reported in human islets. Whether other PPAR types can be found in ... Cited by 79 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] MK Cavaghan, DA Ehrmann, MM Byrne, … - Journal of Clinical …, 1997 - pubmedcentral.nih.gov Impaired glucose tolerance (IGT) is associated with defects in both insulin secretion and action
and carries a high risk for conversion to non–insulin-dependent diabetes mellitus (NIDDM).
Troglitazone, an insulin sensitizing agent, re- duces glucose concentrations in subjects ... Cited by 167 - Related articles - BL Direct - All 10 versions
- ►physiology.org AR Diani, G Sawada, B Wyse, FT Murray, … - American Journal of …, 2004 - Am Physiological Soc Thiazolidinediones may slow the progression of type 2 diabetes by preserving pancreatic
-cells. The effects of pioglitazone (PIO) on structure and function of -cells in KKA(y), C57BL/6J
ob/ob, and C57BL/KsJ db/db mice (genetic models of type 2 diabetes) were examined. ob/ ... Cited by 59 - Related articles - BL Direct - All 4 versions
SA Smith, CA Lister, CDN Toseland, RE … - Diabetes Obesity and …, 2000 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 64 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] A Pick, J Clark, C Kubstrup, M Levisetti, W Pugh, S … - Diabetes, 1998 - Am Diabetes Assoc Page 1. 358 DIABETES, VOL. 47, MARCH 1998 Role of Apoptosis in Failure of
-Cell Mass Compensation for Insulin Resistance and - C ell Defects in the Male
Zucker Diabetic Fatty Rat Anthony Pick, Joshua Clark, Christian ... Cited by 236 - Related articles - All 6 versions
- ►physiology.org F Kawasaki, M Matsuda, Y Kanda, H … - American Journal of …, 2005 - Am Physiological Soc To evaluate preventive effects of pioglitazone on pancreatic -cell damage in C57BL/KsJ db/db
mice, an obese diabetic animal model, the pancreatic islets were compared morphologically
between pioglitazone-treated (100 mg/kg daily po) and untreated db/db mice (n = 7 for ... Cited by 32 - Related articles - All 4 versions
F Ovalle, DSH Bell - Diabetes Obesity and Metabolism, 2002 - interscience.wiley.com Patients and Methods:This is an observational, nested case‐control study. We identified 28 patients
(TZD group), with T2DM, who had had a meal‐stimulated C‐peptide level documented before
the addition of troglitazone to a failing double‐therapy regimen with metformin (MET) and ... Cited by 85 - Related articles - BL Direct - All 3 versions
