X Han, Y Sun, S Scott, D Bleich - Diabetes, 2001 - Am Diabetes Assoc In addition to inhibiting matrix metalloproteinase-2 and matrix metalloproteinase-9 activity, recent
studies suggest that tissue inhibitor of metalloproteinase (TIMP)-1 may inhibit apoptosis in various
cell lines. To address this question in pancreatic islets and β-cells, we treated rat ... Cited by 45 - Related articles - BL Direct - All 6 versions
I Chang, S Kim, JY Kim, N Cho, YH Kim, HS Kim, MK … - Diabetes, 2003 - Am Diabetes Assoc Recent studies incriminating tumor necrosis factor (TNF)- as the final effector in pancreatic
ß-cell death in type 1 diabetes underscore the potential role of TNF- -dependent NF- B activation
as an important modulator of pancreatic ß-cell death in autoimmune diabetes. Although ... Cited by 46 - Related articles - BL Direct - All 5 versions
H Jiang, H Zhu, X Chen, Y Peng, J Wang, F Liu, S Shi, … - Diabetes, 2007 - Am Diabetes Assoc Type 1 diabetes results from autoimmune destruction of the insulin-producing β-cells of pancreatic
islets, of which the capacity for self-replication in the adult is too limited to restore following extensive
tissue injury. Tissue inhibitor of metalloproteinase (TIMP)-1 inhibits matrix ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] G Chen, HE Hohmeier, R Gasa, VV Tran, CB Newgard - Diabetes, 2000 - Am Diabetes Assoc Engineered insulinoma cell lines may represent an alternative to isolated islets for transplantation
ther- apy of type 1 diabetes. Success of this approach may require development of cell lines
that can withstand cytokine-mediated damage. To this end, we have cul- tured INS-1 ... Cited by 47 - Related articles - BL Direct - All 3 versions
- ►aacrjournals.org HS Kim, I Chang, JY Kim, KH Choi, MS Lee - Cancer research, 2005 - AACR Tumor necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL) is cytotoxic to a wide
variety of transformed cells, but not to most normal cells, implying potential therapeutic value
against advanced cancer. However, signal transduction in TRAIL-mediated apoptosis is ... Cited by 14 - Related articles - BL Direct - All 5 versions
N Sekine, T Ishikawa, T Okazaki, M Hayashi, … - Journal of cellular …, 2000 - ncbi.nlm.nih.gov Interferon-gamma (IFN-gamma) is known to exert deleterious effects on pancreatic beta-cells
and is implicated in the development of type 1 (autoimmune) diabetes mellitus. In this study,
we investigated signaling mechanisms mediating the effects of IFN-gamma in pancreatic ... Cited by 31 - Related articles - BL Direct - All 2 versions
[CITATION] IFNγ/TNFα synergism as the final effector in autoimmune diabetes: A key role for …
- ►fasebj.org N Quan, E Ho, W LA, YH Tsai, T Bray - The FASEB Journal, 2001 - FASEB In this study, we tested the hypothesis that nuclear factor B (NF- B) activation is the key event
involved in the initiation of diabetogenesis using alloxan-induced diabetes as a model. Our specific
aims are to determine whether pancreatic NF- B activation induced by alloxan can be ... Cited by 27 - Related articles - BL Direct - All 3 versions
N Giannoukakis, WA Rudert, M Trucco, PD … - Journal of Biological …, 2000 - ASBMB Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that inhibits β cell function and promotes
Fas-triggered apoptosis. IL-1β is thought to act early in the initiation of the autoimmune destruction
of pancreatic β cells in type I diabetes. IL-1β promotes β cell impairment, in part, by ... Cited by 127 - Related articles - BL Direct - All 4 versions
