- ►diabetesjournals.org R Bergeron, SF Previs, GW Cline, P Perret, RR Russell … - Diabetes, 2001 - Am Diabetes Assoc Activation of AMP-activated protein kinase (AMPK) with 5-aminoimidazole-4-carboxamide-1-β
-d-ribofuranoside (AICAR) increases glucose transport in skeletal muscle via an insulin-independent
pathway. To examine the effects of AMPK activation on skeletal muscle glucose transport ... Cited by 134 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org ES Buhl, N Jessen, R Pold, T Ledet, A Flyvbjerg, SB … - Diabetes, 2002 - Am Diabetes Assoc The insulin resistance syndrome is characterized by several risk factors for cardiovascular
disease. Chronic chemical activation of AMP-activated protein kinase by the adenosine analog
5-aminoimidazole-4-carboxamide-1-β -d-ribofuranoside (AICAR) has been shown to ... Cited by 93 - Related articles - BL Direct - All 6 versions
MA Iglesias, JM Ye, G Frangioudakis, AK Saha, E … - Diabetes, 2002 - Am Diabetes Assoc Exercise improves insulin sensitivity. As AMP-activated protein kinase (AMPK) plays an important
role in muscle metabolism during exercise, we investigated the effects of the AMPK activator
5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) on insulin action in ... Cited by 145 - Related articles - BL Direct - All 5 versions
XM Song, M Fiedler, D Galuska, JW Ryder, M … - Diabetologia, 2002 - Springer Type II (non-insulin-dependent) diabetes mellitus is one of the major causes of disability and
death, these being due to the complications accompanying the dis- ease, [1]. Today, the therapeutic
tools commonly uti- lised to treat Type II diabetes mellitus include diet, exercise, ... Cited by 76 - Related articles - BL Direct - All 3 versions
R Bergeron, RR Russell III, LH Young, JM … - American Journal of …, 1999 - Am Physiological Soc The effect of AMP-activated protein kinase (AMPK) activation on skeletal muscle glucose metabolism
was examined in awake rats by infusing them with 5-aminoimidazole-4-carboxamide 1- -D-ribofuranoside
(AICAR; 40 mg/kg bolus and 7.5 mg · kg 1 · min 1 constant infusion) along with a variable ... Cited by 189 - Related articles - BL Direct - All 4 versions
M Foretz, N Ancellin, F Andreelli, Y Saintillan, P … - Diabetes, 2005 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) is a major therapeutic target for the treatment of
diabetes. We investigated the effect of a short-term overexpression of AMPK specifically in the
liver by adenovirus-mediated transfer of a gene encoding a constitutively active form of ... Cited by 102 - Related articles - All 5 versions
MF Vincent, MD Erion, HE Gruber, G Van den Berghe - Diabetologia, 1996 - Springer Summary We have previously demonstrated that in isolated hepatocytes from fasted rats, AICAriboside
(5-amino 4-imidazolecarboxamide riboside), after its conversion into AICAribotide (AICAR or
ZMP), exerts a dose-dependent inhibition on fructose-l,6- bisphosphatase and hence on ... Cited by 56 - Related articles - BL Direct - All 5 versions
B Cool, B Zinker, W Chiou, L Kifle, N Cao, M Perham, R … - Cell metabolism, 2006 - Elsevier AMP-activated protein kinase (AMPK) is a key sensor and regulator of intracellular and
whole-body energy metabolism. We have identified a thienopyridone family of AMPK
activators. A-769662 directly stimulated partially purified rat liver AMPK (EC 50 = 0.8 μM) ... Cited by 91 - Related articles - All 9 versions
- ►endojournals.org F Andreelli, M Foretz, C Knauf, PD Cani, C Perrin, MA … - Endocrinology, 2006 - Endocrine Soc The AMP-activated kinase (AMPK) is a serine threonine kinase that functions as a fuel sensor
to regulate energy balance at both cellular and whole-body levels. Here we studied how hepatic
AMPK 2 isoform affects hepatic glucose production and peripheral glucose uptake in vivo. ... Cited by 62 - Related articles - All 3 versions
