- ►diabetesjournals.org M Iwata, T Haruta, I Usui, Y Takata, A Takano, T Uno, J … - Diabetes, 2001 - Am Diabetes Assoc Tumor necrosis factor (TNF)- is one of the candidate mediators of insulin resistance associated
with obesity, a major risk factor for the development of type 2 diabetes. The insulin resistance
induced by TNF- is antagonized by thiazolidinediones (TZDs), a new class of insulin- ... Cited by 89 - Related articles - BL Direct - All 4 versions
- ►fasebj.org ULF SMITH, S GOGG, A JOHANSSON, T OLAUSSON, … - The FASEB Journal, 2001 - FASEB Thiazolidinediones (TZD) improve insulin sensitivity in human as well as in different animal models
of insulin resistance and Type 2 diabetes. However, no clear link to the insulin signaling events
has been identified. Using differentiated 3T3-L1 adipocytes, we found that TZD rapidly ... Cited by 74 - Related articles - BL Direct - All 2 versions
R Hernandez, T Teruel, C De Alvaro, M Lorenzo - Diabetologia, 2004 - Springer Aims/hypothesis. TNF-α caused insulin resistance on glucose uptake and on insulin signalling
in fetal brown adipocytes. Since treatment with TNF-α acti- vates stress kinases, including c-jun
NH2 terminal ki- nase (JNK), and p42/p44 and p38 mitogen-activated protein kinases ( ... Cited by 33 - Related articles - BL Direct - All 5 versions
K Murase, H Odaka, M Suzuki, N Tayuki, H Ikeda - Diabetologia, 1998 - Springer Summary In order to evaluate the relationship be- tween tumour necrosis factor-a (TNF-a) level
in muscle and metabolic abnormalities in obesity and diabetes mellitus, pioglitazone, a novel
insulin-sensi- tizing agent, was administered to Wistar fatty rats and time-dependent ... Cited by 89 - Related articles - BL Direct - All 3 versions
CA Baumann, N Chokshi, AR Saltiel, V Ribon - Journal of Biological Chemistry, 2000 - ASBMB Although the tyrosine kinase activity of the insulin receptor is essential for the full expression
of insulin action, the precise role of its different cellular substrates remains uncertain. Insulin
stimulates the tyrosine phosphorylation of the c-Cbl proto-oncogene product (1). This ... Cited by 61 - Related articles - BL Direct - All 4 versions
J Rieusset, J Auwerx, H Vidal - Biochemical and Biophysical Research …, 1999 - Elsevier To better define the mechanism of action of the thiazolidinediones, we incubated freshly isolated
human adipocytes with rosiglitazone and investigated the changes in mRNA expression of genes
encoding key proteins of adipose tissue functions. Rosiglitazone (10 −6 M, 4 h) increased ... Cited by 108 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] P Peraldi, M Xu, BM Spiegelman - Journal of Clinical …, 1997 - pubmedcentral.nih.gov TNF- has been shown to be an important mediator of insu- lin resistance linked to obesity. This
cytokine induces insu- lin resistance, at least in part, through inhibition of the ty- rosine kinase
activity of the insulin receptor. Recently, a new class of compounds, the antidiabetic ... Cited by 267 - Related articles - BL Direct - All 9 versions
DM Jia, A Tabaru, T Akiyama, S Abe, M … - … of gastroenterology and …, 2000 - interscience.wiley.com Background and Aims:Troglitazone is a newly developed antidiabetic drug and is indicated to
be useful for the treatment of patients with type II diabetes mellitus. Recently, however, it became
clear that troglitazone could cause liver dysfunction in some patients. In addition, a ... Cited by 21 - Related articles - BL Direct - All 11 versions
RS Ravinuthala, U Nori - Annals of internal medicine, 2000 - ncbi.nlm.nih.gov 1: Ann Intern Med. 2000 Oct 17;133(8):658. Comment on: Ann Intern Med. 2000 Jan
18;132(2):118-21. Ann Intern Med. 2000 Jan 18;132(2):121-4. Rosiglitazone toxicity.
Ravinuthala RS, Nori U. Publication Types: Case Reports; ... Cited by 23 - Related articles - BL Direct - All 2 versions
