S Yakar, JL Liu, AM Fernandez, Y Wu, AV … - Diabetes, 2001 - Am Diabetes Assoc Insulin and insulin-like growth factors (IGFs) mediate a variety of signals
involved in mammalian development and metabolism. To study the metabolic
consequences of IGF-I deficiency, we used the liver IGF-I–deficient (LID) ... Cited by 194 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org K Sjögren, K Wallenius, JL Liu, M Bohlooly-Y, … - Diabetes, 2001 - Am Diabetes Assoc IGF-I is important for postnatal body growth and exhibits insulin-like effects
on carbohydrate metabolism. The function of liver-derived IGF-I is still not
established, although we previously demonstrated that liver-derived IGF-I ... Cited by 80 - Related articles - BL Direct - All 4 versions
- ►nih.gov S Yakar, J Setser, H Zhao, B Stannard, M … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Liver IGF-1–deficient (LID) mice have a 75% reduction in circulating IGF-1
levels and, as a result, a fourfold increase in growth hormone (GH) secretion.
To block GH action, LID mice were crossed with GH antagonist (GHa) ... Cited by 95 - Related articles - BL Direct - All 6 versions
AC Moses, SC Young, LA Morrow, M O'brien … - Diabetes, 1996 - Am Diabetes Assoc Insulin resistance is a major factor in the pathophysiology of type II diabetes
and a major impediment to successful therapy. The identification of treatments
that specifically target insulin resistance could improve diabetes ... Cited by 138 - Related articles - BL Direct - All 4 versions
- ►nih.gov S Yakar, JL Liu, B Stannard, A Butler, D Accili … - Proceedings of the National Academy of Sciences of …, 1999 - National Acad Sciences The somatomedin hypothesis proposed that insulin-like growth factor I (IGF-I)
was a hepatically derived circulating mediator of growth hormone and is a
crucial factor for postnatal growth and development. To reassess this ... Cited by 698 - Related articles - BL Direct - All 8 versions
- ►nih.gov I Ueki, GT Ooi, ML Tremblay, KR Hurst, LA … - Proceedings of the National Academy of Sciences of …, 2000 - National Acad Sciences Insulin-like growth factors (IGFs) I and II are important regulators of cell
proliferation and differentiation. After birth, plasma IGFs, representing mostly
liver-derived IGFs, circulate in ternary complexes of 150 kDa consisting of ... Cited by 70 - Related articles - BL Direct - All 8 versions
R Yu, S Yakar, YL Liu, Y Lu, D LeRoith, D Miao … - Molecular and cellular endocrinology, 2003 - Elsevier Liver-specific IGF-I gene deficient (LID) mice exhibit pancreatic islet
hyperplasia and insulin resistance. To clarify their causal relationship, we
studied age-dependent changes in these two aspects and the response to ... Cited by 16 - Related articles - All 7 versions
MS Sandhu, AH Heald, JM Gibson, JK … - The Lancet, 2002 - Elsevier At 4·5 years of follow-up, 51 (8%) of 615 participants developed impaired
glucose tolerance or type-2 diabetes. After adjustment for correlates of IGF-I
and risk factors for glucose intolerance, the odds ratio for risk of ... Cited by 211 - Related articles - All 6 versions
- ►endojournals.org DR Clemmons, AC Moses, MJ McKay, A … - Journal of Clinical Endocrinology & Metabolism, 2000 - Endocrine Soc Insulin-like growth factor-I (IGF-I) enhances insulin action in normal subjects
and in patients with both type 1 and 2 diabetes; however, its administration is
associated with significant side effects in a high percentage of patients. ... Cited by 131 - Related articles - BL Direct - All 5 versions
- ►cshlp.org AM Fernández, JK Kim, S Yakar, J Dupont, C … - Genes & development, 2001 - genesdev.cshlp.org Peripheral insulin resistance and impaired insulin action are the primary
characteristics of type 2 diabetes. The first observable defect in this major
disorder occurs in muscle, where glucose disposal in response to insulin is ... Cited by 136 - Related articles - BL Direct - All 5 versions
