- ►diabetesjournals.org PH Ducluzeau, N Perretti, M Laville, F Andreelli, N … - Diabetes, 2001 - Am Diabetes Assoc Defective regulation of gene expression may be involved in the pathogenesis of type 2
diabetes. We have characterized the concerted regulation by insulin (3-h hyperinsulinemic
clamp) of the expression of 10 genes related to insulin action in skeletal muscle and in ... Cited by 150 - Related articles - BL Direct - All 5 versions
C Sewter, D Berger, RV Considine, G Medina, J … - Diabetes, 2002 - Am Diabetes Assoc Sterol regulatory element binding protein (SREBP)-1 is a transcription factor with important roles
in the control of fatty acid metabolism and adipogenesis. Little information is available regarding
the expression of this molecule in human health or disease. Exposure of isolated human ... Cited by 85 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org I Guillet-Deniau, V Mieulet, S Le Lay, Y Achouri, D … - Diabetes, 2002 - Am Diabetes Assoc Sterol regulatory element binding protein-1c (SREBP-1c) is a transcription factor that mediates
insulin effects on hepatic gene expression. It is itself transcriptionally stimulated by insulin in
hepatocytes. Here we show that SREBP-1c mRNA is expressed in adult rat skeletal ... Cited by 62 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] M Pendergrass, J Koval, C Vogt, H Yki-Jarvinen, P … - Diabetes, 1998 - Am Diabetes Assoc NIDDM and obesity are characterized by decreased insulin-stimulated glucose uptake in
muscle. It has been suggested that impaired glucose phosphorylation to
glucose-6-phosphate, catalyzed in muscle by hexo- kinase (HK)II, may contribute to this ... Cited by 68 - Related articles - BL Direct - All 6 versions
F Andreelli, M Laville, PH Ducluzeau, N Vega, P Vallier … - Diabetologia, 1999 - Springer Summary We investigated the regulation of the mRNA expression of the insulin receptor, insulin
re- ceptor substrate-1 (IRS-1) and p85a-phosphatidyli- nositol-3-kinase (PI-3K), three major actors
of insu- lin action, in skeletal muscle from 10 healthy lean vol- unteers, 13 obese patients ... Cited by 54 - Related articles - BL Direct - All 4 versions
M Kolehmainen, H Vidal, E Alhava, MIJ Uusitupa - Obesity, 2001 - nature.com Discussion: SREBP-1c mRNA expression was lower in omental adipose tissue than in subcutaneous
depots in obese subjects before weight loss. Furthermore, the expression of SREBP-1c in obese
subjects was clearly lower than in normal weight subjects, but mRNA levels increased ... Cited by 35 - Related articles - BL Direct - All 2 versions
H Oberkofler, N Fukushima, H Esterbauer, F … - BBA-Gene Structure and …, 2002 - Elsevier Sterol regulatory element binding proteins (SREBPs) are transcription factors that are involved
in adipogenesis and regulate the expression of genes controlling cholesterol and fatty acid
biosynthesis. Animal experiments indicate that SREBP-1a, -1c, and -2 have distinct ... Cited by 18 - Related articles - All 5 versions
F Andreelli, M Laville, N Vega, JP Riou, H Vidal - Diabetologia, 2000 - Springer 2]. Insulin action and glucose, lipid and protein me- tabolism are perturbed in diabetic
patients. Although the initial causes are still not known, these alterations result from changes
in the activity of key enzymes, mainly due to post-translational modifications of pro- teins ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] D Azzout-Marniche, D Becard, C Guichard, M … - Biochemical …, 2000 - pubmedcentral.nih.gov The transcription factor sterol regulatory-element-binding protein-1c (SREBP-1c) plays a major
role in the effect of insulin on the transcription of hepatic genes such as glucokinase and fatty
acid synthase. We show here in cultured rat hepatocytes that insulin, through activation of ... Cited by 148 - Related articles - BL Direct - All 6 versions
