- ►diabetesjournals.org N Stefan, A Fritsche, H Häring, M Stumvoll - Diabetes, 2001 - Am Diabetes Assoc The transcription of many genes involved in lipid metabolism is regulated by the peroxisome
proliferator–activated receptor- (PPAR- ). The Pro12Ala polymorphism in the PPAR- 2 gene has
been associated with reduced transcriptional activity in vitro and increased insulin ... Cited by 47 - Related articles - BL Direct - All 4 versions
M Stumvoll, H Häring - Diabetologia, 2002 - Springer To the editor: We read with interest the letter by Lindi et al. in the July issue of Diabetologia, reporting
the influence of the common Pro12Ala polymorphism in the peroxisome-prolifer- ator-activated
receptor ± PPARg 2 ± on long-term weight change [1]. Over a 10-year period those who ... Cited by 21 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org H Mori, H Ikegami, Y Kawaguchi, S Seino, N Yokoi, J … - Diabetes, 2001 - Am Diabetes Assoc The allele frequencies for a Pro 12 →Ala substitution in peroxisome proliferator–activated
receptor-γ differ among ethnic groups, and its relationship with diabetes and associated diseases
is controversial. The prevalence of this polymorphism and its effects on clinical ... Cited by 163 - Related articles - BL Direct - All 5 versions
M Koch, K Rett, E Maerker, A Volk, K Haist, M Deninger … - Diabetologia, 1999 - Springer The peroxisome proliferator activated receptors (PPAR) are members of the nuclear hormone
recep- tor superfamily which act as transcription factors reg- ulating important mechanisms in
adipocyte differen- tiation. Natural ligands of PPAR's are prostaglandin J2 and ... Cited by 87 - Related articles - BL Direct - All 4 versions
R Buzzetti, A Petrone, MC Ribaudo, I Alemanno, … - European Journal of …, 2004 - nature.com Several genetic variants of peroxisome proliferator-activated receptor- 2 (PPAR- 2) have been
identified, among which Pro12Ala, a missense mutation in exon 2, is highly prevalent in Caucasian
populations. Up to now, conflicting results with regard to the association between this ... Cited by 33 - Related articles - BL Direct - All 3 versions
BJ Nicklas, EFC van Rossum, DM Berman, AS Ryan, … - Diabetes, 2001 - Am Diabetes Assoc This study determined the effects of the peroxisome proliferator–activated receptor (PPAR)-γ2
Pro12Ala variant on body composition and metabolism and the magnitude of weight regain in
70 postmenopausal women (BMI 25–40 kg/m 2 ) who completed 6 months of a ... Cited by 87 - Related articles - BL Direct - All 5 versions
S Jacob, M Stumvoll, R Becker, M Koch, M … - Horm Metab …, 2000 - thieme-connect.com Recently, a highly prevalent polymorphism of the PPAR?2-receptor (Pro12Ala) was described
and found to be associated with reduced transcriptional activity. Both human and animal studies
suggested that this polymorphism may be associated with increased insulin sensitivity. ... Cited by 54 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org M Stumvoll, HG Wahl, K Löblein, R Becker, F Machicao … - Diabetes, 2001 - Am Diabetes Assoc The Pro12Ala polymorphism of the peroxisome proliferator–activated receptor (PPAR)-γ 2 is
associated with reduced transcriptional activity in vitro and increased insulin sensitivity in humans
in vivo. The mechanism by which this polymorphism influences insulin sensitivity in ... Cited by 88 - Related articles - BL Direct - All 4 versions
- ►physiology.org E Qvigstad, IL Mostad, KS Bjerve, VE … - American Journal of …, 2003 - Am Physiological Soc We tested the effects of acute perturbations of elevated fatty acids (FA) on insulin secretion in
type 2 diabetes. Twenty-one type 2 diabetes subjects with hypertriglyceridemia (triacylglycerol
>2.2 mmol/l) and 10 age-matched nondiabetic subjects participated. Glucose-stimulated ... Cited by 21 - Related articles - BL Direct - All 4 versions
V Tavares, RD Hirata, AC Rodrigues, O Monte … - Diab Obesity …, 2005 - interscience.wiley.com Methods: Genomic DNA was obtained from 207 unrelated white people presenting with
T2Dm and from 170 controls. Anthropometric data included body mass index and waist to hip
ratio. Biochemical parameters included fasting plasma glucose, total cholesterol, high- ... Cited by 26 - Related articles - BL Direct - All 4 versions
