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Diabetic Embryopathy in C57BL/6J Mice


… Machado, EF Zimmerman, DN Hovland Jr … - …, 2001 - diabetes.diabetesjournals.org.p. …
Maternal diabetes (types 1 and 2) induces a broad array of congenital malformations, including
neural tube defects (NTDs), in humans. One of the difficulties associated with studying diabetic
embryopathy is the rarity of individual malformations. In an attempt to develop a sensitive ...
Cited by 25 - Related articles - BL Direct - All 7 versions

In vivo evidence for the existence of a threshold for hyperglycemia-induced major …


A Torchinsky, V Toder, H Carp, H Orenstein, … - Early pregnancy: biology …, 1997 - ncbi.nlm.nih.gov
The present study was carried out to evaluate whether hyperglycemia-induced major fetal anomalies
are thresholded phenomena. Streptozotocin (STZ)-treated female ICR mice were examined on
day 19 of pregnancy by methods routinely used in Segment II teratological studies. ...
Cited by 17 - Related articles

TNF-a acts to prevent occurrence of malformed fetuses in diabetic mice


A Torchinsky, M Gongadze, H Orenstein, S Savion, A … - Diabetologia, 2004 - Springer
Aims/hypothesis. Activation of apoptosis in embryos is thought to be a key event in the pathogenesis
of dia- betes-induced embryopathies such as early embryonic death and inborn structural
anomalies. TNF-α can ac- tivate apoptotic and anti-apoptotic signalling cascades, ...
Cited by 16 - Related articles - BL Direct - All 5 versions

Immunostimulation increases the resistance of mouse embryos to the teratogenic …


A Torchinsky, V Toder, S Savion, J Shepshelovich, H … - Diabetologia, 1997 - Springer
Studies aimed at eliciting the etiology and the pathogenesis of these malformations suggested
that the latter may be due to interaction between diabe- tes-associated teratogenic metabolites
(eg glucose, ketone bodies, somatomedin inhibitors) and some in- ternal factors, which ...
Cited by 29 - Related articles - BL Direct - All 3 versions

TNF-a-Mediated Stress-Induced Early Pregnancy Loss: A Possible Role of …


A Torchinsky, U Markert, V Toder - Chemical immunology and …, 2005 - content.karger.com
Markert UR (ed): Immunology of Pregnancy. Chem Immunol Allergy. Basel, Karger, 2005, vol
89, pp 62–71 ... A. Torchinsky a , UR Markert b , V. Toder a ... Abstract Background: Leukemia
inhibitory factor (LIF) is at present suggested to be essential for implantation in mammals. ...
Cited by 10 - Related articles - BL Direct - All 7 versions

Oxidative stress during diabetic pregnancy disrupts cardiac neural crest migration …


SC Morgan, F Relaix, LL Sandell, MR … - Birth Defects Research … - interscience.wiley.com
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Cited by 9 - Related articles - All 2 versions

Exposure of neural crest cells to elevated glucose leads to congenital heart defects …


PA Roest, L van Iperen, S Vis, LJ Wisse, … - … RESEARCH PART A …, 2007 - interscience.wiley.com
It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ...
Cited by 10 - Related articles - BL Direct - All 3 versions

Maternal diabetes induces congenital heart defects in mice by altering the …


SD Kumar, ST Dheen, SSW Tay - Cardiovascular Diabetology, 2007 - cardiab.com
We analyzed the morphological changes, the expression pattern of some genes, the proliferation
index and apoptosis in developing heart of embryos at E13.5 from streptozotocin-induced diabetic
mice. Morphological analysis has shown the persistent truncus arteriosus combined with ...
Cited by 10 - Related articles - Cached - All 9 versions

Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin- …


A Wiznitzer, N Ayalon, R Hershkovitz, M Khamaisi, … - American journal of …, 1999 - Elsevier
Lipoic acid is a naturally occurring antioxidant capable of inducing its activity in both a lipophilic
and an aqueous milieu. 17 Presently its main clinical application is in the treatment of diabetic
polyneuropathy. 18 Lipoic acid is an effective hydroxyl and hypochlorous acid (HOCl) ...
Cited by 24 - Related articles - BL Direct - All 7 versions

Increased TNF-alpha expression in cultured mouse embryos exposed to …

- reproduction-online.org [PDF] 
A Torchinsky, I Brokhman, J Shepshelovich, H … - Reproduction, 2003 - Soc Reprod Fertility
Diabetes-induced early embryonic death is accompanied by an increased expression of tumour
necrosis factor (TNF- ) in the embryonic microenvironment. The aim of the present study was
to evaluate whether diabetes- induced embryopathic stress may also alter the expression ...
Cited by 13 - Related articles - BL Direct - All 3 versions


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