- ►diabetesjournals.org AK Cardozo, M Kruhøffer, R Leeman, T Ørntoft, … - Diabetes, 2001 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease resulting from the selective
destruction of insulin-producing β-cells. Cytokines may contribute to
pancreatic β-cell death in type 1 diabetes. β-cell exposure to ... Cited by 145 - Related articles - BL Direct - All 4 versions
- ►daegu.ac.kr [PDF] B Kutlu, AK Cardozo, MI Darville, M Kruhoffer, … - DIABETES-NEW YORK-, 2003 - Am Diabetes Assoc Locally released cytokines contribute to -cell dysfunc- tion and apoptosis in
type 1 diabetes. In vitro exposure of insulin-producing INS-1E cells to the
cytokines inter- leukin (IL)-1 interferon (IFN)- leads to a signifi- cant ... Cited by 91 - Related articles - BL Direct - All 7 versions
AK Cardozo, H Heimberg, Y Heremans, R Leeman … - Journal of Biological Chemistry, 2001 - ASBMB Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic
-cells. Cytokines, such as interleukin-1 and interferon- , are putative
mediators of immune-induced -cell death and, under in vitro conditions, ... Cited by 158 - Related articles - BL Direct - All 4 versions
AK Cardozo, M Kruhøffer, R Leeman, T Ørntoft, … - DIABETES, 2001 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease resulting from the selective
destruction of insulin-producing -cells. Cytokines may contribute to pancreatic
-cell death in type 1 diabetes. -cell exposure to interleukin (IL)-1 ... Related articles
- ►daegu.ac.kr [PDF] J Rasschaert, D Liu, B Kutlu, AK Cardozo, M … - Diabetologia, 2003 - Springer Aims/hypothesis. Viral infections and local production of IFN-γ might
contribute to beta-cell dysfunction/ death in Type 1 Diabetes. Double stranded
RNA (dsRNA) accumulates in the cytosol of viral-infected cells, and ... Cited by 41 - Related articles - BL Direct - All 4 versions
AK Cardozo, P Proost, C Gysemans, MC Chen, … - Diabetologia, 2003 - Springer Aims/hypothesis. Cytokines and chemokines are im- portant mediators of immune
responses due to their ability to recruit and activate leukocytes. Using micro-
array analysis we observed that rat beta cells exposed to IL-1β and IFN-γ ... Cited by 85 - Related articles - BL Direct - All 5 versions
- ►daegu.ac.kr [PDF] DL Eizirik, T Mandrup-Poulsen - Diabetologia, 2001 - Springer Apoptosis is likely to be the main form of beta-cell death in immune-mediated
diabetes mellitus in ro- dents and possibly in humans. Clarification of the
regulation of beta-cell death could indicate novel sites for therapeutic ... Cited by 320 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org H Heimberg, Y Heremans, C Jobin, R Leemans, … - Diabetes, 2001 - Am Diabetes Assoc Cytokine-induced β-cell death is an important event in the pathogenesis of type
1 diabetes. The transcription factor nuclear factor-κB (NF-κB) is activated by
interleukin-1β (IL-1β), and its activity promotes the expression of ... Cited by 129 - Related articles - BL Direct - All 4 versions
N Giannoukakis, WA Rudert, M Trucco, PD … - Journal of Biological Chemistry, 2000 - ASBMB Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that inhibits β cell
function and promotes Fas-triggered apoptosis. IL-1β is thought to act early in
the initiation of the autoimmune destruction of pancreatic β cells in type ... Cited by 127 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] D Liu, D Pavlovic, MC Chen, M Flodström, S … - Diabetes, 2000 - Am Diabetes Assoc Prolonged exposure of rodent -cells to combinations of cytokines induces the
inducible form of nitric oxide synthase (iNOS) expression and Fas expression,
nitric oxide (NO) production, and cell death. It also induces the ... Cited by 165 - Related articles - BL Direct - All 5 versions
