JC Lee, SB Smith, H Watada, J Lin, D Scheel, J Wang, … - Diabetes, 2001 - Am Diabetes Assoc Neurogenin3 (ngn3), a basic helix-loop-helix (bHLH) transcription factor, functions as a pro-endocrine
factor in the developing pancreas: by itself, it is sufficient to force undifferentiated pancreatic epithelial
cells to become islet cells. Because ngn3 expression determines which precursor cells ... Cited by 98 - Related articles - BL Direct - All 5 versions
- ►nih.gov P Jacquemin, SM Durviaux, J Jensen, C … - Molecular and Cellular …, 2000 - Am Soc Microbiol Hepatocyte nuclear factor 6 (HNF-6) is the prototype of a new class of cut homeodomain transcription
factors. During mouse development, HNF-6 is expressed in the epithelial cells that are precursors
of the exocrine and endocrine pancreatic cells. We have investigated the role of HNF-6 in ... Cited by 138 - Related articles - BL Direct - All 5 versions
J Hald, JP Hjorth, MS German, OD Madsen, P Serup, J … - Developmental Biology, 2003 - Elsevier Mice carrying loss-of-function mutations in certain Notch pathway genes display increased and
accelerated pancreatic endocrine development, leading to depletion of precursor cells followed
by pancreatic hypoplasia. Here, we have investigated the effect of expressing a ... Cited by 91 - Related articles - All 4 versions
CS Lee, DD De León, KH Kaestner, DA Stoffers - DIABETES, 2006 - Am Diabetes Assoc Neurogenin3 (ngn3), a basic helix-loop-helix (bHLH) transcription factor, functions as a pro-endocrine
factor in the developing pancreas: by itself, it is sufficient to force undifferentiated pancreatic epithelial
cells to be- come islet cells. Because ngn3 expression determines which precursor cells ... Related articles - All 2 versions
- ►biologists.org [PDF] VM Schwitzgebel, DW Scheel, JR Conners, J … - Development, 2000 - dev.biologists.org The pancreas forms from dorsal and ventral buds that appear at the foregut-midgut junction starting
at embryonic day (E)9.5 in the mouse. Over the subsequent 10 days of fetal development, these
two apparently uniform clusters of epithelial cells differentiate into the cell types that ... Cited by 313 - Related articles - BL Direct - All 3 versions
- ►jbc.org SB Smith, R Gasa, H Watada, J Wang, SC Griffen, … - Journal of Biological …, 2003 - ASBMB During fetal development, paired/homeodomain transcription factor Pax4 controls the formation
of the insulin-producing cells and the somatostatin-producing cells in the islets of Langerhans
in the pancreas. Targeting of Pax4 expression to the islet lineage in the fetal pancreas ... Cited by 47 - Related articles - BL Direct - All 4 versions
G Gradwohl, A Dierich, M LeMeur, F … - Proceedings of the …, 2000 - National Acad Sciences In the mammalian pancreas, the endocrine cell types of the islets of Langerhans, including the
α-, β-, δ-, and pancreatic polypeptide cells as well as the exocrine cells, derive from foregut endodermal
progenitors. Recent genetic studies have identified a network of transcription factors, ... Cited by 490 - Related articles - BL Direct - All 8 versions
- ►nih.gov HP Huang, M Liu, HM El-Hodiri, K Chu, M … - Molecular and cellular …, 2000 - Am Soc Microbiol The BETA2 (neuroD) gene is expressed in endocrine cells during pancreas development and
is essential for proper islet morphogenesis. The objective of this study is to identify potential upstream
regulators of the BETA2 gene during pancreas development. We demonstrated that the ... Cited by 137 - Related articles - BL Direct - All 4 versions
Å Apelqvist, H Li, L Sommer, P Beatus, DJ Anderson, T … - Nature, 1999 - nature.com The pancreas contains both exocrine and endocrine cells, but the molecular mechanisms controlling
the differentiation of these cell types are largely unknown. Despite their endodermal origin, pancreatic
endocrine cells share several molecular characteristics with neurons 1, 2, 3, 4, 5 , and, ... Cited by 511 - Related articles - BL Direct - All 5 versions
- ►pnas.org LC Murtaugh, BZ Stanger, KM Kwan, … - Proceedings of the …, 2003 - National Acad Sciences Multiple cell types of the pancreas appear asynchronously during embryogenesis, which requires
that pancreatic progenitor cell potential changes over time. Loss-of-function studies have shown
that Notch signaling modulates the differentiation of these progenitors, but it remains ... Cited by 164 - Related articles - BL Direct - All 10 versions
