- ►diabetesjournals.org LO'Rourke, SJ Yeaman, PR Shepherd - Diabetes, 2001 - Am Diabetes Assoc Leptin is produced in adipose tissue and acts in the hypothalamus to regulate
food intake. However, recent evidence also indicates a potential for direct
roles for leptin in peripheral tissues, including those of the immune ... Cited by 63 - Related articles - BL Direct - All 4 versions
GR van den Brink, T O'Toole, JCH Hardwick, … - Molecular Cell Biology Research Communications, 2000 - Elsevier The adipocyte-derived hormone leptin plays an important role as a relayer of
nutritional status to several organ systems. Evidence is accumulating that
leptin plays an important role in the adequate functioning and maintenance ... Cited by 43 - Related articles - BL Direct - All 3 versions
F Maingrette, G Renier - Diabetes, 2003 - Am Diabetes Assoc Recent data suggest that plasma leptin may represent a cardiovascular risk
factor in diabetic patients. To gain further insight into the role of leptin in
atherogenesis associated with diabetes, we investigated in the present ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►jbc.org L O'Rourke, LM Gronning, SJ Yeaman, PR … - Journal of Biological Chemistry, 2002 - ASBMB Insulin resistance, obesity, and diabetes are characterized by hyperglycemia,
hyperinsulinemia, and hyperleptinemia and are associated with increased risk of
atherosclerosis. In an effort to understand how this occurs, we have ... Cited by 67 - Related articles - BL Direct - All 6 versions
SM Kang, HM Kwon, BK Hong, D Kim, IJ Kim, … - Yonsei Med J, 2000 - kmbase.medric.or.kr Neovascularization of the adventitial vasa vasorum with extension into the
intima of atherosclerotic lesions is frequently observed, but its
pathophysiological significance is still subject to debate. Recently, ... Cited by 64 - Related articles - Cached - BL Direct - All 10 versions
M Ciccone, R Vettor, N Pannacciulli, A … - Int J Obes Relat Metab Disord, 2001 - bases.bireme.br OBJECTIVE: To investigate whether intima-media thickness (IMT) of the common
carotid artery (CCA), an early marker of asymptomatic atherosclerosis, is
significantly and independently associated with plasma concentrations of ... Cited by 110 - Related articles - Cached - BL Direct - All 3 versions
J Sundell, R Huupponen, OT Raitakari, P … - Obesity, 2003 - nature.com Results: Serum leptin was significantly higher in obese than nonobese subjects
(10.3 5.6 vs. 4.3 2.5 ng/mL, p < 0.01). Basal myocardial blood flow was not
significantly different between obese and nonobese subjects. Adenosine- ... Cited by 18 - Related articles - BL Direct - All 4 versions
E Porreca, C Di Febbo, L Fusco, V Moretta, M … - Atherosclerosis, 2004 - Elsevier Recent studies have suggested that leptin, a plasma protein secreted by
adipocytes, may play a role in artherothrombosis. In this study, we tested the
hypothesis that leptin contributes to in vivo endothelial dysfunction in ... Cited by 19 - Related articles - All 8 versions
M Ozata, F Avcu, O Durmus, I Yilmaz, IC … - Obesity, 2001 - nature.com Results: Our results show that patients with the leptin gene mutation (both the
homozygous and heterozygous patients) had significantly higher ADP-induced (78.3
3.4% vs. 57.9 9.3%, p = 0.001), collagen-induced (78.1 2.9% vs. 56.7 9.3%, ... Cited by 19 - Related articles - BL Direct - All 3 versions
J Harvey, NG McKay, KS Walker, J Van der … - Journal of Biological Chemistry, 2000 - ASBMB The mechanism by which leptin increases ATP-sensitive K + (K ATP ) channel
activity was investigated using the insulin-secreting cell line, CRI-G1.
Wortmannin and LY 294002, inhibitors of phosphoinositide 3-kinase ... Cited by 89 - Related articles - BL Direct - All 4 versions
