- ►diabetesjournals.org TA Kinard, PB Goforth, Q Tao, ME Abood, J … - Diabetes, 2001 - Am Diabetes Assoc Insulin-secreting pancreatic islet β-cells possess anion-permeable Cl −
channels (I Cl,islet ) that are swelling-activated, but the role of these
channels in the cells is unclear. The Cl − channel blockers 4,4′- ... Cited by 13 - Related articles - BL Direct - All 7 versions
G Drews, G Zempel, P Krippeit-Drews, S … - BBA-Biomembranes, 1998 - Elsevier Osmotic cell swelling is described to activate ion efflux mechanisms in B-cells
responsible for regulatory cell volume decrease [1, 2, 3, 4], to depolarize the
cells [5], and to increase insulin release transiently [1, 6, 7]. It has ... Cited by 23 - Related articles - All 5 versions
- ►physiology.org SG Straub, S Daniel, GWG Sharp - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc Exposure of HC9 cells to a Krebs-Ringer bicarbonate-HEPES buffer (KRBH) made
hypotonic by a reduction of 25 mM NaCl resulted in a prompt stimulation of
insulin release. The stimulation was transient, and release rates returned ... Cited by 17 - Related articles - BL Direct - All 5 versions
R Beauwens, L Best, N Markedieu, R Crutzen, … - Endocrine, 2006 - Springer Received November 21, 2006; Revised December 15, 2006; Accepted December 21,
2006. Author to whom all correspondence and reprint requests should be
addressed: Prof. WJ Malaisse, Laboratory of Experimental Hormonology, ... Cited by 6 - Related articles - BL Direct - All 3 versions
- ►physoc.org [PDF] L Best, HE Miley, AP Yates - Experimental physiology, 1996 - Physiological Soc Experimental Physiology (1996), 81, 927-933 Printed in Great Britain ...
ACTIVATION OF AN ANION CONDUCTANCE AND f-CELL DEPOLARIZATION DURING
HYPOTONICALLY INDUCED INSULIN RELEASE ... L. BEST, HE MILEY AND AP YATES Cited by 38 - Related articles - BL Direct - All 7 versions
L Best - BBA-Biomembranes, 2000 - Elsevier The perforated patch technique was used to assess the relative contribution of K
ATP channel activity, assessed from input conductance (G input ), and
volume-sensitive anion channel activity to the induction of electrical ... Cited by 14 - Related articles - All 3 versions
- ►physiology.org M Takii, T Ishikawa, H Tsuda, K Kanatani, T … - American Journal of Physiology- Cell Physiology, 2006 - Am Physiological Soc In isolated rat pancreatic -cells, hypotonic stimulation elicited an increase in
cytosolic Ca 2+ concentration ([Ca 2+ ] c ) at 2.8 mM glucose. The hypotonically
induced [Ca 2+ ] c elevation was significantly suppressed by nicardipine, a ... Cited by 1 - Related articles - BL Direct - All 3 versions
EA Sheader, PD Brown, L Best - Molecular and Cellular Endocrinology, 2001 - Elsevier Exposure of insulin-secreting cells to hypotonic solutions causes cell swelling
followed by regulatory volume decrease (RVD). We have previously demonstrated
that RVD is due to activation of a Cl − conductance. The present study ... Cited by 16 - Related articles - All 3 versions
L Best - Cellular signalling, 2002 - Elsevier The antioestrogen 4-hydroxytamoxifen (10 or 2 μM) abolished the generation of
action potentials and repolarized the membrane potential in rat pancreatic
β-cells stimulated by 16 mM glucose. This effect was slowly reversible ... Cited by 17 - Related articles - BL Direct - All 6 versions
- ►nih.gov [PDF] HE Miley, EA Sheader, PD Brown, L Best - The Journal of Physiology, 1997 - pubmedcentral.nih.gov 1. Changes in relative cell volume in response to hypotonic solutions and
glucose were studied in single isolated rat pancreatic fl-cells using a
video-imaging technique. fl-cell electrical activity was recorded under ... Cited by 42 - Related articles - BL Direct - All 8 versions
