A Imagawa, T Hanafusa, S Tamura, M Moriwaki, N Itoh, … - Diabetes, 2001 - Am Diabetes Assoc To better understand the pathogenesis of type 1 diabetes, we have developed pancreatic biopsy
under laparoscope for recent-onset type 1 diabetic patients. The patients included 29 acute-onset
type 1 diabetic patients, 5 latent-onset type 1 diabetic patients, and 1 type 2 diabetic ... Cited by 84 - Related articles - BL Direct - All 7 versions
- ►nih.gov [PDF] N Itoh, T Hanafusa, A Miyazaki, J … - Journal of Clinical …, 1993 - pubmedcentral.nih.gov We examined pancreas biopsy specimens from 18 newly diag- nosed insulin-dependent diabetes
mellitus (IDDM) patients to elucidate the mechanism underlying beta cell destruction. Pan- creas
islets were seen in all patients and insulitis in eight pa- tients. Infiltrating mononuclear ... Cited by 160 - Related articles - BL Direct - All 8 versions
M Füchtenbusch, W Rabl, B Grassl, W Bachmann, E … - Diabetologia, 1998 - Springer Type 1 diabetes is an autoimmune disorder in which the destruction of insulin-producing
beta-cells can be detected years before the clinical manifestation of the disease [1]. Selective
autoantibody assays and me- tabolic testing can now identify first degree relatives of Type ... Cited by 73 - Related articles - BL Direct - All 5 versions
M Moriwaki, N Itoh, J Miyagawa, K Yamamoto, A … - Diabetologia, 1999 - Springer Type I (insulin-dependent) diabetes mellitus is thought to be a cell-mediated autoimmune disease
characterized by the selective destruction of pancreat- ic betacells [1,2].Severallinesof
evidencehaveestab- lished a critical role for autoreactive lymphocytes in the ... Cited by 101 - Related articles - BL Direct - All 3 versions
A Imagawa, T Hanafusa, JI Miyagawa, Y … - Annals of …, 2000 - informahealthcare.com To better understand the pathogenesis of type 1 diabetes, our group performed a pathological
examination on the pancreas tissue of recent-onset type 1 diabetics and analysed their clinical
characteristics. These studies led us to speculate that there are three distinct subtypes of ... Cited by 30 - Related articles - BL Direct - All 5 versions
A Imagawa, T Hanafusa, J Miyagawa, Y … - New England Journal of …, 2000 - content.nejm.org Results We divided the patients into three groups: 36 patients with positive tests for serum glutamic
acid decarboxylase antibodies, 9 with negative tests for serum glutamic acid decarboxylase antibodies
and glycosylated hemoglobin values higher than 11.5 percent, and 11 with negative tests ... Cited by 219 - Related articles - BL Direct - All 6 versions
JM LaGasse, MS Brantley, NJ Leech, RE Rowe, S … - Diabetes Care, 2002 - Am Diabetes Assoc RESULTS—Six subjects developed diabetes (median interval 2.8 years), all from among the
12 individuals with multiple d-aab, representing 50% positive predictive value (95% CI
25–75%) and 100% sensitivity (58–100%). Among the others, diabetes occurred in 0 of 6 ... Cited by 76 - Related articles - BL Direct - All 5 versions
A Hanninen - Scandinavian Journal of Immunology, 2000 - 万方数据资源系统 Mucosal immune response to an antigen leads to a state of attenuated systemic response to
the same antigen, known as mucosal or oral tolerance. Thus, autoantigen administration via
mucosal routes could be useful in the prevention of autoimmune diseases. Although in ... Cited by 22 - Related articles - BL Direct - All 3 versions
S Martin, NK van Den Engel, A Vinke, E Heidenthal, … - Journal of Autoimmunity, 2001 - Elsevier Intercellular adhesion molecule (ICAM)-1 is involved in forming the immunological synapse.
The contribution of ICAM-1 to immune responses is not critical because mice with a disrupted
ICAM-1 gene do not have grossly abnormal immune reactivity. Here we report on the ... Cited by 21 - Related articles - BL Direct - All 5 versions
A Imagawa, T Hanafusa, N Itoh, M Waguri, K … - Diabetologia, 1999 - Springer Type I (insulin-dependent) diabetes mellitus results from the selective destruction of pancreatic
beta cells ... Immunological abnormalities in islets at diagnosis paralleled ... A. Imagawa 1 ,
T. Hanafusa 1 , N. Itoh 2 , M. Waguri 1 , K. Yamamoto 1 , J. Miyagawa 1 , M. Moriwaki 1 , ... Cited by 20 - Related articles - BL Direct - All 3 versions
