- ►diabetesjournals.org M Federici, M Hribal, L Perego, M Ranalli, Z … - Diabetes, 2001 - Am Diabetes Assoc Type 2 diabetes is characterized by insulin resistance and inadequate insulin
secretion. In the advanced stages of the disease, β-cell dysfunction worsens
and insulin therapy may be necessary to achieve satisfactory metabolic ... Cited by 175 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org K Maedler, GA Spinas, R Lehmann, P Sergeev … - Diabetes, 2001 - Am Diabetes Assoc In autoimmune type 1 diabetes, Fas–to–Fas-ligand (FasL) interaction may
represent one of the essential pro-apoptotic pathways leading to a loss of
pancreatic ß-cells. In the advanced stages of type 2 diabetes, a decline ... Cited by 195 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] MY Donath, DJ Gross, E Cerasi, N Kaiser - Diabetes, 1999 - Am Diabetes Assoc The gerbil Psammomys obesus develops nutrition- dependent diabetes associated
with moderate obesity. The disease is characterized by initial hyperinsulinemia,
progressing to hypoinsulinemia associated with depleted pancreatic insulin ... Cited by 224 - Related articles - BL Direct - All 5 versions
- ►pnas.org K Maedler, A Fontana, F Ris, P Sergeev, C … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences Type 2 diabetes mellitus results from an inadequate adaptation of the functional
pancreatic β cell mass in the face of insulin resistance. Changes in the
concentration of glucose play an essential role in the regulation of β ... Cited by 96 - Related articles - BL Direct - All 11 versions
- ►jbc.org IB Efanova, SV Zaitsev, B Zhivotovsky, M … - Journal of Biological Chemistry, 1998 - ASBMB High concentrations of glucose are considered to be toxic for the pancreatic
-cell. However, the mechanisms underlying -cell dysfunction and resulting cell
death are not fully characterized. In the present study we have ... Cited by 234 - Related articles - BL Direct - All 6 versions
- ►nih.gov K Maedler, P Sergeev, F Ris, J Oberholzer, … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to
pancreatic β cells, causing impaired insulin secretion. IL-1β is a
proinflammatory cytokine acting during the autoimmune process of type 1 ... Cited by 329 - Related articles - BL Direct - All 7 versions
K Maedler, GA Spinas, D Dyntar, W Moritz, N … - Diabetes, 2001 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function
observed in type 2 diabetes. Here we examine the effect of saturated and
unsaturated fatty acids at different glucose concentrations on β-cell ... Cited by 223 - Related articles - BL Direct - All 7 versions
S Marshak, G Leibowitz, F Bertuzzi, C Socci, N … - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc In type 2 diabetes, chronic hyperglycemia has been sug- gested to be detrimental
to -cell function, causing reduced glucose-stimulated insulin secretion and dis-
proportionately elevated proinsulin. In the present study, we investigated ... Cited by 111 - Related articles - BL Direct - All 5 versions
N KAISER, AP CORCOS, INA SAREL, E … - Endocrinology, 1991 - Endocrine Soc * This work was supported by grants from the Wolfson Foundation, the Fund for
Basic Research administered by the Israel Academy of Sciences and Humanities,
and the George Grandis Endowment for Medical Research. A portion of this ... Cited by 57 - Related articles - All 3 versions
- ►endocrinology-journals.org [PDF] S Bonner-Weir - Journal of molecular endocrinology, 2000 - Soc Endocrinology Diabetes mellitus, whether type 1 (insulin- dependent diabetes mellitus; IDDM)
or type 2 (non- insulin-dependent diabetes mellitus; NIDDM) results from an
inadequate mass of functional pancreatic -cells. In the first case, the ... Cited by 196 - Related articles - BL Direct - All 5 versions
